Screening for in vivo (anti)estrogenic and (anti)androgenic activities of Tropaeolum majus L. and its effect on uterine contractility

Emerson Luiz Botelho Loureno, Juliane Centeno Muller, Ana Claudia Boareto, Caroline Gomes, Ana Carolina Loureno, Bruna Minatovicz, Sandra Crestani, Arquimedes Gasparotto, Anderson Joel Martino-Andrade, Paulo Roberto Dalsenter

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18 Scopus citations


Ethnopharmacological relevance: Tropaeolum majus L. (Tropaeolaceae) is a medicinal herb popularly used in Brazil for treatment of inflammatory and cardiovascular diseases. Despite some published data on its efficacy, there are still few toxicological data describing the safety of this plant. The aim of this study was to evaluate the (anti)estrogenic and (anti)androgenic activity of the hydroethanolic extract obtained from Tropaeolum majus L. (HETM), as well as its possible effects on uterine contractility. Materials and methods: Three experimental protocols were performed, (a) uterotrophic assay, (b) Hershberger assay and (c) an ex vivo test to investigate the effects of maternal administration of HETM on uterine contractility at the end of pregnancy. In all protocols three doses of the HETM were administered to Wistar rats: 3, 30 and 300 mg/kg. Results: In vivo tests for detection of (anti)androgenic and (anti)estrogenic activities did not show any significant alterations. Similarly, no alterations were observed on uterine contractility induced by oxytocin and arachidonic acid. Conclusions: HETM was unable to produce (anti)estrogenic or (anti)androgenic activities in the short-term in vivo screening assays performed. In addition, there was no evidence that HETM can affect uterine contractility following gestational exposure of rats.

Original languageEnglish
Pages (from-to)418-423
Number of pages6
JournalJournal of Ethnopharmacology
Issue number1
StatePublished - 7 May 2012
Externally publishedYes


  • Medicinal herbs
  • Rats
  • Reproductive toxicology
  • Tropaeolum majus


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