Sclerosing cholangitis after continuous hepatic artery infusion of FUDR

M. M. Kemeny, H. Battifora, D. W. Blayney, G. Cecchi, D. A. Goldberg, L. A. Leong, K. A. Margolin, J. J. Terz

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


Eight of 46 (17.4%) patients treated in our trial of continuous hepatic artery infusion (CHAI) of fluorodeoxyuridine (FUDR) by Infusaid® pump developed biliary strictures. The lesions were clinically, radiographically, and pathologically identical to the idiopathic sclerosing cholangitis frequently seen in association with inflammatory bowel disease. Treatment included immediate cessation of intraarterial FUDR, and surgical or percutaneous drainage of the biliary tree if it was dilated. Two of the eight patients died of the complication. Three patients stabilized after biliary system drainage, and two patients improved on observation only. The pathogenesis of this complication is not understood. This report details the clinical and pathological features of this entity.

Original languageEnglish
Pages (from-to)176-181
Number of pages6
JournalAnnals of Surgery
Issue number2
StatePublished - 1985
Externally publishedYes


Dive into the research topics of 'Sclerosing cholangitis after continuous hepatic artery infusion of FUDR'. Together they form a unique fingerprint.

Cite this