Sclerosing cholangitis after continuous hepatic artery infusion of FUDR

M. M. Kemeny; H. Battifora; D. W. Blayney; G. Cecchi; D. A. Goldberg; L. A. Leong; K. A. Margolin; J. J. Terz

doi:10.1097/00000658-198508000-00007

Sclerosing cholangitis after continuous hepatic artery infusion of FUDR

M. M. Kemeny, H. Battifora, D. W. Blayney, G. Cecchi, D. A. Goldberg, L. A. Leong, K. A. Margolin, J. J. Terz

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Abstract

Eight of 46 (17.4%) patients treated in our trial of continuous hepatic artery infusion (CHAI) of fluorodeoxyuridine (FUDR) by Infusaid® pump developed biliary strictures. The lesions were clinically, radiographically, and pathologically identical to the idiopathic sclerosing cholangitis frequently seen in association with inflammatory bowel disease. Treatment included immediate cessation of intraarterial FUDR, and surgical or percutaneous drainage of the biliary tree if it was dilated. Two of the eight patients died of the complication. Three patients stabilized after biliary system drainage, and two patients improved on observation only. The pathogenesis of this complication is not understood. This report details the clinical and pathological features of this entity.

Original language	English
Pages (from-to)	176-181
Number of pages	6
Journal	Annals of Surgery
Volume	202
Issue number	2
DOIs	https://doi.org/10.1097/00000658-198508000-00007
State	Published - 1985
Externally published	Yes

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title = "Sclerosing cholangitis after continuous hepatic artery infusion of FUDR",

abstract = "Eight of 46 (17.4%) patients treated in our trial of continuous hepatic artery infusion (CHAI) of fluorodeoxyuridine (FUDR) by Infusaid{\textregistered} pump developed biliary strictures. The lesions were clinically, radiographically, and pathologically identical to the idiopathic sclerosing cholangitis frequently seen in association with inflammatory bowel disease. Treatment included immediate cessation of intraarterial FUDR, and surgical or percutaneous drainage of the biliary tree if it was dilated. Two of the eight patients died of the complication. Three patients stabilized after biliary system drainage, and two patients improved on observation only. The pathogenesis of this complication is not understood. This report details the clinical and pathological features of this entity.",

author = "Kemeny, {M. M.} and H. Battifora and Blayney, {D. W.} and G. Cecchi and Goldberg, {D. A.} and Leong, {L. A.} and Margolin, {K. A.} and Terz, {J. J.}",

year = "1985",

doi = "10.1097/00000658-198508000-00007",

language = "English",

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journal = "Annals of Surgery",

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TY - JOUR

T1 - Sclerosing cholangitis after continuous hepatic artery infusion of FUDR

AU - Kemeny, M. M.

AU - Battifora, H.

AU - Blayney, D. W.

AU - Cecchi, G.

AU - Goldberg, D. A.

AU - Leong, L. A.

AU - Margolin, K. A.

AU - Terz, J. J.

PY - 1985

Y1 - 1985

N2 - Eight of 46 (17.4%) patients treated in our trial of continuous hepatic artery infusion (CHAI) of fluorodeoxyuridine (FUDR) by Infusaid® pump developed biliary strictures. The lesions were clinically, radiographically, and pathologically identical to the idiopathic sclerosing cholangitis frequently seen in association with inflammatory bowel disease. Treatment included immediate cessation of intraarterial FUDR, and surgical or percutaneous drainage of the biliary tree if it was dilated. Two of the eight patients died of the complication. Three patients stabilized after biliary system drainage, and two patients improved on observation only. The pathogenesis of this complication is not understood. This report details the clinical and pathological features of this entity.

AB - Eight of 46 (17.4%) patients treated in our trial of continuous hepatic artery infusion (CHAI) of fluorodeoxyuridine (FUDR) by Infusaid® pump developed biliary strictures. The lesions were clinically, radiographically, and pathologically identical to the idiopathic sclerosing cholangitis frequently seen in association with inflammatory bowel disease. Treatment included immediate cessation of intraarterial FUDR, and surgical or percutaneous drainage of the biliary tree if it was dilated. Two of the eight patients died of the complication. Three patients stabilized after biliary system drainage, and two patients improved on observation only. The pathogenesis of this complication is not understood. This report details the clinical and pathological features of this entity.

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DO - 10.1097/00000658-198508000-00007

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SN - 0003-4932

VL - 202

SP - 176

EP - 181

JO - Annals of Surgery

JF - Annals of Surgery

IS - 2

ER -

Sclerosing cholangitis after continuous hepatic artery infusion of FUDR

Abstract

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