TY - JOUR
T1 - Sclerosing angiomatoid nodular transformation (SANT) of the spleen
T2 - A report of 3 cases
AU - Koreishi, Aashiyana F.
AU - Saenz, Adam J.
AU - Fleming, Stephen E.
AU - Teruya-Feldstein, Julie
PY - 2009/10
Y1 - 2009/10
N2 - The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.
AB - The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.
KW - Hamartoma
KW - Hemangioma
KW - PET scan
KW - SANT
KW - Sclerosing angiomatoid nodular transformation
KW - Spleen
UR - http://www.scopus.com/inward/record.url?scp=70349556311&partnerID=8YFLogxK
U2 - 10.1177/1066896909342568
DO - 10.1177/1066896909342568
M3 - Article
C2 - 19666947
AN - SCOPUS:70349556311
SN - 1066-8969
VL - 17
SP - 384
EP - 389
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 5
ER -