Sclerosing angiomatoid nodular transformation (SANT) of the spleen: A report of 3 cases

Aashiyana F. Koreishi, Adam J. Saenz, Stephen E. Fleming, Julie Teruya-Feldstein

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23 Scopus citations


The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalInternational Journal of Surgical Pathology
Issue number5
StatePublished - Oct 2009
Externally publishedYes


  • Hamartoma
  • Hemangioma
  • PET scan
  • SANT
  • Sclerosing angiomatoid nodular transformation
  • Spleen


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