Scleroderma in association with the use of bleomycin: A report of 3 cases

L. D. Kerr, H. Spiera

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54 Scopus citations

Abstract

Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported. We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U. Dramatic clinical improvement occurred in 2 patients treated with high dose steroids. Our series of 3 patients supports a causal connection between bleomycin and scleroderma. In light of the widespread use of bleomycin, this complication may be under-appreciated.

Original languageEnglish
Pages (from-to)294-296
Number of pages3
JournalJournal of Rheumatology
Volume19
Issue number2
StatePublished - 1992

Keywords

  • bleomycin
  • scleroderma

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