@article{029a012e3bc049d192af504a33a3f6d1,
title = "Scleral hyperplasia induced by heat",
abstract = "We evaluated low-level heating as a stimulus to induce hyperplasia of normal rabbit sclera. Heat treatments were administered by placing an etched-element heater on bare sclera. Contact thermotherapy with a conductive device provided a favorable dose distribution for local scleral heating. A purely conductive heat source was selected to minimize intraocular heat penetration and to determine whether the scleral reaction was a primary thermal effect. Histologic examination of treated specimens showed thickening of normal rabbit sclera with preservation of the underlying normal ocular structures. Electron microscopic examination of treated sclera showed newly formed collagen fibrils adjacent to sclerocytes. These fibroblasts were activated, as manifested by well-developed rough-surfaced endoplasmic reticulum and hypertrophic Golgi complexes.",
author = "Finger, {Paul T.} and Curtin, {Brian J.} and Samuel Packer and Svitra, {Paul P.} and Takeo Iwamoto and Whitmore, {Wayne G.} and Jakobiec, {Frederick A.}",
note = "Funding Information: From the Manhattan Eye, Ear, and Throat Hospital, Departments of Ophthalmology and Pathology, New York, New York (Drs. Finger, Curtin, Packer, Whitmore, and Jakobiec); the Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (Dr. Finger); the Medical Department, Brookhaven National Laboratory, Upton, New York (Drs. Finger, Packer, and Svitra); Cornell University Medical College, North Shore University Hospital, Division of Ophthalmology, Manhasset, New York (Drs: Finger and Packer); Cornell University Medical Center, Department of Ophthalmology, New York, New York (Drs. Packer and Iwamoto); and Columbia University, College of Physicians and Surgeons, Department of Ophthalmology, New York, New York (Drs. Curtin and [akobiec). This study was supported by the Myopia Fund of Manhattan Eye, Ear, and Throat Hospital, and Department of Energy contract DE-AC02-7600016. Dr. [akobiec is the recipient of the Research to Prevent Blindness Robert E. McCormick Scholar Award.",
year = "1986",
month = jul,
day = "15",
doi = "10.1016/0002-9394(86)90204-7",
language = "English",
volume = "102",
pages = "25--32",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier Inc.",
number = "1",
}