SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection

Qian Wang; Zeynep H. Gümüş; Cristina Colarossi; Lorenzo Memeo; Xintong Wang; Chung Yin Kong; Paolo Boffetta

doi:10.1016/j.jtho.2022.10.002

SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection

Qian Wang, Zeynep H. Gümüş, Cristina Colarossi, Lorenzo Memeo, Xintong Wang, Chung Yin Kong, Paolo Boffetta

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

We review research regarding the epidemiology, risk factors, genetic susceptibility, molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of lung cancers. We first summarize the changing incidences of SCLC globally and in the United States among males and females. We then review the established risk factor (i.e., tobacco smoking) and suspected nonsmoking-related risk factors for SCLC, and emphasize the importance of continued effort in tobacco control worldwide. Review of genetic susceptibility and molecular pathology suggests different molecular pathways in SCLC development compared with other types of lung cancer. Last, we comment on the limited utility of low-dose computed tomography screening in SCLC and on several promising blood-based molecular biomarkers as potential tools in SCLC early detection.

Original language	English
Pages (from-to)	31-46
Number of pages	16
Journal	Journal of Thoracic Oncology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.jtho.2022.10.002
State	Published - Jan 2023

Keywords

Biomarkers
Early detection
Epidemiology
Genetic susceptibility
Molecular pathology
Small cell lung cancer

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10.1016/j.jtho.2022.10.002

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title = "SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection",

abstract = "We review research regarding the epidemiology, risk factors, genetic susceptibility, molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of lung cancers. We first summarize the changing incidences of SCLC globally and in the United States among males and females. We then review the established risk factor (i.e., tobacco smoking) and suspected nonsmoking-related risk factors for SCLC, and emphasize the importance of continued effort in tobacco control worldwide. Review of genetic susceptibility and molecular pathology suggests different molecular pathways in SCLC development compared with other types of lung cancer. Last, we comment on the limited utility of low-dose computed tomography screening in SCLC and on several promising blood-based molecular biomarkers as potential tools in SCLC early detection.",

keywords = "Biomarkers, Early detection, Epidemiology, Genetic susceptibility, Molecular pathology, Small cell lung cancer",

author = "Qian Wang and G{\"u}m{\"u}{\c s}, {Zeynep H.} and Cristina Colarossi and Lorenzo Memeo and Xintong Wang and Kong, {Chung Yin} and Paolo Boffetta",

note = "Funding Information: Disclosure: Dr. G{\"u}m{\"u}{\c s} gratefully acknowledges funding from the LUNGevity Foundation . The remaining authors declare no conflict of interest. Publisher Copyright: {\textcopyright} 2022 International Association for the Study of Lung Cancer",

year = "2023",

month = jan,

doi = "10.1016/j.jtho.2022.10.002",

language = "English",

volume = "18",

pages = "31--46",

journal = "Journal of Thoracic Oncology",

issn = "1556-0864",

publisher = "International Association for the Study of Lung Cancer",

number = "1",

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T1 - SCLC

T2 - Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection

AU - Wang, Qian

AU - Gümüş, Zeynep H.

AU - Colarossi, Cristina

AU - Memeo, Lorenzo

AU - Wang, Xintong

AU - Kong, Chung Yin

AU - Boffetta, Paolo

N1 - Funding Information: Disclosure: Dr. Gümüş gratefully acknowledges funding from the LUNGevity Foundation . The remaining authors declare no conflict of interest. Publisher Copyright: © 2022 International Association for the Study of Lung Cancer

PY - 2023/1

Y1 - 2023/1

N2 - We review research regarding the epidemiology, risk factors, genetic susceptibility, molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of lung cancers. We first summarize the changing incidences of SCLC globally and in the United States among males and females. We then review the established risk factor (i.e., tobacco smoking) and suspected nonsmoking-related risk factors for SCLC, and emphasize the importance of continued effort in tobacco control worldwide. Review of genetic susceptibility and molecular pathology suggests different molecular pathways in SCLC development compared with other types of lung cancer. Last, we comment on the limited utility of low-dose computed tomography screening in SCLC and on several promising blood-based molecular biomarkers as potential tools in SCLC early detection.

AB - We review research regarding the epidemiology, risk factors, genetic susceptibility, molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of lung cancers. We first summarize the changing incidences of SCLC globally and in the United States among males and females. We then review the established risk factor (i.e., tobacco smoking) and suspected nonsmoking-related risk factors for SCLC, and emphasize the importance of continued effort in tobacco control worldwide. Review of genetic susceptibility and molecular pathology suggests different molecular pathways in SCLC development compared with other types of lung cancer. Last, we comment on the limited utility of low-dose computed tomography screening in SCLC and on several promising blood-based molecular biomarkers as potential tools in SCLC early detection.

KW - Biomarkers

KW - Early detection

KW - Epidemiology

KW - Genetic susceptibility

KW - Molecular pathology

KW - Small cell lung cancer

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U2 - 10.1016/j.jtho.2022.10.002

DO - 10.1016/j.jtho.2022.10.002

M3 - Review article

C2 - 36243387

AN - SCOPUS:85141313793

SN - 1556-0864

VL - 18

SP - 31

EP - 46

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

IS - 1

ER -

SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection

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Keywords

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