Schizophrenia dissection by five anxiety and depressive subtype comorbidities: Clinical implications and evolutionary perspective

André B. Veras, Simone Cougo, Fernanda Meira, Clayton Peixoto, Jorge A. Barros, Antonio E. Nardi, Dolores Malaspina, Michael Poyurovsky, Jeffrey P. Kahn

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Twenty patients with DSM5 schizophrenia were comprehensively and formally assessed by an experienced psychiatrist. All subjects were assessed for: positive and negative psychotic symptoms; social anxiety; panic anxiety; obsessive compulsive disorder, atypical depression; major depression; suicide risk; and global assessment of functioning. Different profiles of clinical presentation and symptom evolution emerged for patients with schizophrenia who had co-morbid depression (15%), OCD (15%), panic or limited symptom attacks (55%) and social anxiety (5%). At least eighty percent of the sample had one or more of these co-morbidities. Summing up, the data support our previous finding that panic is highly prevalent in Schizophrenia with Auditory Hallucinations (>73% here, versus 100% before), and panic was paroxysmally concurrent with voice onset. Moreover, characteristic clinical findings may help point clinicians to five specific co-morbidity psychosis subtypes. Moreover, co-morbidity dissection of psychotic diagnoses recalls and parallels the historical psychopharmacologic dissection of non-psychotic anxiety and depressive subtypes diagnoses. Larger studies should further test and explore these preliminary findings.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalPsychiatry Research
Volume257
DOIs
StatePublished - Nov 2017
Externally publishedYes

Keywords

  • Atypical Depression
  • Comorbidity
  • Evolution
  • Melancholia
  • OCD
  • Panic
  • Psychiatry
  • Schizophrenia
  • Social Anxiety

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