Scanning electron microscopy after coronary transluminal angioplasty of normal canine coronary arteries

Richard C. Pasternak, Kenneth L. Baughman, John T. Fallon, Peter C. Block

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Percutaneous coronary transluminal angioplasty is currently being proposed as a possible treatment for some patients with significant coronary arterial lesions. In this study scanning electron microscopy was used to assess the morphologic changes caused by the angioplasty balloon catheter in normal canine coronary arteries. Balloon inflation uniformly caused endothelial denudation with virtually immediate dense platelet adhesion to the subendothelial matrix. This platelet adhesion was unaffected by pretreatment with aspirin (35 mg/kg body weight) or heparin (2,000 units). However, intravenous administration of low molecular weight dextran almost completely prevented platelet adhesion to the exposed subendothelial connective tissues. It is concluded that even in normal canine coronary arteries (1) loss of endothelium is seen after transluminal angioplasty; (2) this endothelial damage stimulates platelet adhesion and thrombus formation; and (3) the immediate layering of platelets can be prevented by administration of low molecular weight dextran.

Original languageEnglish
Pages (from-to)591-598
Number of pages8
JournalAmerican Journal of Cardiology
Volume45
Issue number3
DOIs
StatePublished - Mar 1980
Externally publishedYes

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