Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture

Vishal Patel; Ming Chang Chiang; Paul M. Thompson; Katie L. McMahon; Greig I. De Zubicaray; Nicholas G. Martin; Margaret J. Wright; Arthur W. Toga

doi:10.1109/ISBI.2010.5490187

Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture

Vishal Patel, Ming Chang Chiang, Paul M. Thompson, Katie L. McMahon, Greig I. De Zubicaray, Nicholas G. Martin, Margaret J. Wright, Arthur W. Toga

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

10 Scopus citations

Abstract

Recent advances in diffusion-weighted MRI (DWI) have enabled studies of complex white matter tissue architecture in vivo. To date, the underlying influence of genetic and environmental factors in determining central nervous system connectivity has not been widely studied. In this work, we introduce new scalar connectivity measures based on a computationally-efficient fast-marching algorithm for quantitative tractography. We then calculate connectivity maps for a DTI dataset from 92 healthy adult twins and decompose the genetic and environmental contributions to the variance in these metrics using structural equation models. By combining these techniques, we generate the first maps to directly examine genetic and environmental contributions to brain connectivity in humans. Our approach is capable of extracting statistically significant measures of genetic and environmental contributions to neural connectivity.

Original language	English
Title of host publication	2010 7th IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	From Nano to Macro, ISBI 2010 - Proceedings
Pages	1109-1112
Number of pages	4
DOIs	https://doi.org/10.1109/ISBI.2010.5490187
State	Published - 2010
Externally published	Yes
Event	7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands Duration: 14 Apr 2010 → 17 Apr 2010

Publication series

Name	2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

Conference

Conference	7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
Country/Territory	Netherlands
City	Rotterdam
Period	14/04/10 → 17/04/10

Keywords

Algorithms
Brain
Genetics
Magnetic resonance imaging
Nervous system

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10.1109/ISBI.2010.5490187

Cite this

Patel, V., Chiang, M. C., Thompson, P. M., McMahon, K. L., De Zubicaray, G. I., Martin, N. G., Wright, M. J., & Toga, A. W. (2010). Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 1109-1112). Article 5490187 (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). https://doi.org/10.1109/ISBI.2010.5490187

Patel, Vishal ; Chiang, Ming Chang ; Thompson, Paul M. et al. / Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture. 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. pp. 1109-1112 (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings).

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title = "Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture",

abstract = "Recent advances in diffusion-weighted MRI (DWI) have enabled studies of complex white matter tissue architecture in vivo. To date, the underlying influence of genetic and environmental factors in determining central nervous system connectivity has not been widely studied. In this work, we introduce new scalar connectivity measures based on a computationally-efficient fast-marching algorithm for quantitative tractography. We then calculate connectivity maps for a DTI dataset from 92 healthy adult twins and decompose the genetic and environmental contributions to the variance in these metrics using structural equation models. By combining these techniques, we generate the first maps to directly examine genetic and environmental contributions to brain connectivity in humans. Our approach is capable of extracting statistically significant measures of genetic and environmental contributions to neural connectivity.",

keywords = "Algorithms, Brain, Genetics, Magnetic resonance imaging, Nervous system",

author = "Vishal Patel and Chiang, {Ming Chang} and Thompson, {Paul M.} and McMahon, {Katie L.} and {De Zubicaray}, {Greig I.} and Martin, {Nicholas G.} and Wright, {Margaret J.} and Toga, {Arthur W.}",

year = "2010",

doi = "10.1109/ISBI.2010.5490187",

language = "English",

isbn = "9781424441266",

series = "2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings",

pages = "1109--1112",

booktitle = "2010 7th IEEE International Symposium on Biomedical Imaging",

note = "7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 ; Conference date: 14-04-2010 Through 17-04-2010",

}

Patel, V, Chiang, MC, Thompson, PM, McMahon, KL, De Zubicaray, GI, Martin, NG, Wright, MJ & Toga, AW 2010, Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture. in 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings., 5490187, 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings, pp. 1109-1112, 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010, Rotterdam, Netherlands, 14/04/10. https://doi.org/10.1109/ISBI.2010.5490187

Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture. / Patel, Vishal; Chiang, Ming Chang; Thompson, Paul M. et al.
2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. p. 1109-1112 5490187 (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - De Zubicaray, Greig I.

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Patel V, Chiang MC, Thompson PM, McMahon KL, De Zubicaray GI, Martin NG et al. Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. p. 1109-1112. 5490187. (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). doi: 10.1109/ISBI.2010.5490187

Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture

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