Scaffolds for Tendon and Ligament Repair and Regeneration

Anthony Ratcliffe; David L. Butler; Nathaniel A. Dyment; Paul J. Cagle; Christopher S. Proctor; Seena S. Ratcliffe; Evan L. Flatow

doi:10.1007/s10439-015-1263-1

Scaffolds for Tendon and Ligament Repair and Regeneration

Anthony Ratcliffe, David L. Butler, Nathaniel A. Dyment, Paul J. Cagle, Christopher S. Proctor, Seena S. Ratcliffe, Evan L. Flatow

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Enhanced tendon and ligament repair would have a major impact on orthopedic surgery outcomes, resulting in reduced repair failures and repeat surgeries, more rapid return to function, and reduced health care costs. Scaffolds have been used for mechanical and biologic reinforcement of repair and regeneration with mixed results. This review summarizes efforts made using biologic and synthetic scaffolds using rotator cuff and ACL as examples of clinical applications, discusses recent advances that have shown promising clinical outcomes, and provides insight into future therapy.

Original language	English
Pages (from-to)	819-831
Number of pages	13
Journal	Annals of Biomedical Engineering
Volume	43
Issue number	3
DOIs	https://doi.org/10.1007/s10439-015-1263-1
State	Published - 1 Mar 2015

Keywords

ACL repair
Augmentation
Clinical repair of tendon
Healing
Ligament
Regeneration
Reinforcement
Rotator cuff
Scaffold
Tendon
Tensile properties
Tensile stiffness
Tensile strength

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abstract = "Enhanced tendon and ligament repair would have a major impact on orthopedic surgery outcomes, resulting in reduced repair failures and repeat surgeries, more rapid return to function, and reduced health care costs. Scaffolds have been used for mechanical and biologic reinforcement of repair and regeneration with mixed results. This review summarizes efforts made using biologic and synthetic scaffolds using rotator cuff and ACL as examples of clinical applications, discusses recent advances that have shown promising clinical outcomes, and provides insight into future therapy.",

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AU - Butler, David L.

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AU - Proctor, Christopher S.

AU - Ratcliffe, Seena S.

AU - Flatow, Evan L.

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AB - Enhanced tendon and ligament repair would have a major impact on orthopedic surgery outcomes, resulting in reduced repair failures and repeat surgeries, more rapid return to function, and reduced health care costs. Scaffolds have been used for mechanical and biologic reinforcement of repair and regeneration with mixed results. This review summarizes efforts made using biologic and synthetic scaffolds using rotator cuff and ACL as examples of clinical applications, discusses recent advances that have shown promising clinical outcomes, and provides insight into future therapy.

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KW - Healing

KW - Ligament

KW - Regeneration

KW - Reinforcement

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KW - Scaffold

KW - Tendon

KW - Tensile properties

KW - Tensile stiffness

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Scaffolds for Tendon and Ligament Repair and Regeneration

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Keywords

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