Scaffolds for Tendon and Ligament Repair and Regeneration

Anthony Ratcliffe, David L. Butler, Nathaniel A. Dyment, Paul J. Cagle, Christopher S. Proctor, Seena S. Ratcliffe, Evan L. Flatow

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Enhanced tendon and ligament repair would have a major impact on orthopedic surgery outcomes, resulting in reduced repair failures and repeat surgeries, more rapid return to function, and reduced health care costs. Scaffolds have been used for mechanical and biologic reinforcement of repair and regeneration with mixed results. This review summarizes efforts made using biologic and synthetic scaffolds using rotator cuff and ACL as examples of clinical applications, discusses recent advances that have shown promising clinical outcomes, and provides insight into future therapy.

Original languageEnglish
Pages (from-to)819-831
Number of pages13
JournalAnnals of Biomedical Engineering
Issue number3
StatePublished - 1 Mar 2015


  • ACL repair
  • Augmentation
  • Clinical repair of tendon
  • Healing
  • Ligament
  • Regeneration
  • Reinforcement
  • Rotator cuff
  • Scaffold
  • Tendon
  • Tensile properties
  • Tensile stiffness
  • Tensile strength


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