Saturation-recovery metabolic-exchange rate imaging with hyperpolarized [1-13C] pyruvate using spectral-spatial excitation

Rolf F. Schulte, Jonathan I. Sperl, Eliane Weidl, Marion I. Menzel, Martin A. Janich, Oleksandr Khegai, Markus Durst, Jan Henrik Ardenkjaer-Larsen, Steffen J. Glaser, Axel Haase, Markus Schwaiger, Florian Wiesinger

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Within the last decade hyperpolarized [1-13C] pyruvate chemical-shift imaging has demonstrated impressive potential for metabolic MR imaging for a wide range of applications in oncology, cardiology, and neurology. In this work, a highly efficient pulse sequence is described for time-resolved, multislice chemical shift imaging of the injected substrate and obtained downstream metabolites. Using spectral-spatial excitation in combination with single-shot spiral data acquisition, the overall encoding is evenly distributed between excitation and signal reception, allowing the encoding of one full two-dimensional metabolite image per excitation. The signal-to-noise ratio can be flexibly adjusted and optimized using lower flip angles for the pyruvate substrate and larger ones for the downstream metabolites. Selectively adjusting the excitation of the down-stream metabolites to 90° leads to a so-called "saturation-recovery" scheme with the detected signal content being determined by forward conversion of the available pyruvate. In case of repetitive excitations, the polarization is preserved using smaller flip angles for pyruvate. Metabolic exchange rates are determined spatially resolved from the metabolite images using a simplified two-site exchange model. This novel contrast is an important step toward more quantitative metabolic imaging. Goal of this work was to derive, analyze, and implement this "saturation- recovery metabolic exchange rate imaging" and demonstrate its capabilities in four rats bearing subcutaneous tumors.

Original languageEnglish
Pages (from-to)1209-1216
Number of pages8
JournalMagnetic Resonance in Medicine
Volume69
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Keywords

  • hyperpolarization
  • magnetic resonance spectroscopy
  • metabolic exchange rate
  • metabolic imaging
  • pyruvate
  • saturation-recovery
  • spectral-spatial excitation

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