TY - JOUR
T1 - SARS-CoV-2-related MIS-C
T2 - A key to the viral and genetic causes of Kawasaki disease?
AU - MIS-CCHGE
AU - Sancho-Shimizu, Vanessa
AU - Brodin, Petter
AU - Cobat, Aurélie
AU - Biggs, Catherine M.
AU - Toubiana, Julie
AU - Lucas, Carrie L.
AU - Henrickson, Sarah E.
AU - Belot, Alexandre
AU - Tangye, Stuart G.
AU - Milner, Joshua D.
AU - Levin, Michael
AU - Abel, Laurent
AU - Bogunovic, Dusan
AU - Casanova, Jean Laurent
AU - Zhang, Shen Ying
AU - Haddad, Elie
AU - Beland, Kathie
AU - Pujol, Aurora
AU - Schlüter, Agatha
AU - Planas-Serra, Laura
AU - Aguilera-Albesa, Sergio
AU - Valencia-Ramos, Juan
AU - Rodríguez-Palmero, Agustí
AU - Gut, Marta
AU - Rivière, Jacques G.
AU - Colobran, Roger
AU - Soler-Palacin, Pere
AU - Rodriguez-Gallego, Carlos
AU - de Diego, Rebeca Perez
AU - Flores, Carlos
AU - Alsina, Laia
AU - Blazquez-Gamero, Daniel
AU - Jordan, Iolanda
AU - Keles, Sevgi
AU - Emiroglu, Melike
AU - Akcan, Ozge Metin
AU - Alkan, Gulsum
AU - Aytekin, Selma Erol
AU - Gul, Yahya
AU - Tüter Öz, Şadiye Kübra
AU - Bozdemir, Sefika Elmas
AU - Bayhan, Gulsum Iclal
AU - Yüksek, Saliha Kanık
AU - Parlakay, Aslınur Özkaya
AU - Gülhan, Belgin
AU - Yahşi, Aysun
AU - Kilic, Ahmet Osman
AU - Karbuz, Adem
AU - Erdeniz, Emine Hafize
AU - Itan, Yuval
N1 - Publisher Copyright:
© 2021 Sancho-Shimizu et al.
PY - 2021/4/27
Y1 - 2021/4/27
N2 - Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
AB - Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
UR - http://www.scopus.com/inward/record.url?scp=85105542114&partnerID=8YFLogxK
U2 - 10.1084/jem.20210446
DO - 10.1084/jem.20210446
M3 - Review article
C2 - 33904890
AN - SCOPUS:85105542114
SN - 0022-1007
VL - 218
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 6
M1 - e20210446
ER -