Sarcoma antigen in surgical patients: A clinical study

J. Sethi; Y. Hirshaut; H. Kesselheim; B. Maclean; G. Fortner

Sarcoma antigen in surgical patients: A clinical study

J. Sethi
, Y. Hirshaut
, H. Kesselheim
, B. Maclean
, G. Fortner

Research output: Contribution to journal › Article › peer-review

Abstract

A complement-fixing antigen common to human sarcomas, tentatively called S ₃, has previously been described. Initial observations indicated that S ₃ antibody levels rise sharply following surgical removal of tumors. A prospective study was, therefore, undertaken to evaluate the clinical significance of alterations in S ₃Ab levels. Serial samples collected from patients prior to surgery, and at 2 wk and at 2 mo were analyzed for S ₃AB levels. The increase in S ₃Ab titre was found to be fourfold or greater as a consequence of surgery. Patients remaining free of disease-circulating S ₃Ab levels gradually decreased, patients eventually becoming seronegative. However, with persistent tumor, S ₃Ab levels tended to remain elevated.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Clinical and Investigative Medicine
Volume	2
Issue number	2-3
State	Published - 1979
Externally published	Yes

Cite this

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title = "Sarcoma antigen in surgical patients: A clinical study",

abstract = "A complement-fixing antigen common to human sarcomas, tentatively called S 3, has previously been described. Initial observations indicated that S 3 antibody levels rise sharply following surgical removal of tumors. A prospective study was, therefore, undertaken to evaluate the clinical significance of alterations in S 3Ab levels. Serial samples collected from patients prior to surgery, and at 2 wk and at 2 mo were analyzed for S 3AB levels. The increase in S 3Ab titre was found to be fourfold or greater as a consequence of surgery. Patients remaining free of disease-circulating S 3Ab levels gradually decreased, patients eventually becoming seronegative. However, with persistent tumor, S 3Ab levels tended to remain elevated.",

author = "J. Sethi and Y. Hirshaut and H. Kesselheim and B. Maclean and G. Fortner",

year = "1979",

language = "English",

volume = "2",

pages = "89--92",

journal = "Clinical and Investigative Medicine",

issn = "0147-958X",

publisher = "The Canadian Society for Clinical Investigation",

number = "2-3",

}

TY - JOUR

T1 - Sarcoma antigen in surgical patients

T2 - A clinical study

AU - Sethi, J.

AU - Hirshaut, Y.

AU - Kesselheim, H.

AU - Maclean, B.

AU - Fortner, G.

PY - 1979

Y1 - 1979

N2 - A complement-fixing antigen common to human sarcomas, tentatively called S 3, has previously been described. Initial observations indicated that S 3 antibody levels rise sharply following surgical removal of tumors. A prospective study was, therefore, undertaken to evaluate the clinical significance of alterations in S 3Ab levels. Serial samples collected from patients prior to surgery, and at 2 wk and at 2 mo were analyzed for S 3AB levels. The increase in S 3Ab titre was found to be fourfold or greater as a consequence of surgery. Patients remaining free of disease-circulating S 3Ab levels gradually decreased, patients eventually becoming seronegative. However, with persistent tumor, S 3Ab levels tended to remain elevated.

AB - A complement-fixing antigen common to human sarcomas, tentatively called S 3, has previously been described. Initial observations indicated that S 3 antibody levels rise sharply following surgical removal of tumors. A prospective study was, therefore, undertaken to evaluate the clinical significance of alterations in S 3Ab levels. Serial samples collected from patients prior to surgery, and at 2 wk and at 2 mo were analyzed for S 3AB levels. The increase in S 3Ab titre was found to be fourfold or greater as a consequence of surgery. Patients remaining free of disease-circulating S 3Ab levels gradually decreased, patients eventually becoming seronegative. However, with persistent tumor, S 3Ab levels tended to remain elevated.

UR - https://www.scopus.com/pages/publications/0018688092

M3 - Article

C2 - 533637

AN - SCOPUS:0018688092

SN - 0147-958X

VL - 2

SP - 89

EP - 92

JO - Clinical and Investigative Medicine

JF - Clinical and Investigative Medicine

IS - 2-3

ER -

Sarcoma antigen in surgical patients: A clinical study

Abstract

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