Sarcoma antigen in surgical patients: A clinical study

J. Sethi, Y. Hirshaut, H. Kesselheim, B. Maclean, G. Fortner

Research output: Contribution to journalArticlepeer-review


A complement-fixing antigen common to human sarcomas, tentatively called S 3, has previously been described. Initial observations indicated that S 3 antibody levels rise sharply following surgical removal of tumors. A prospective study was, therefore, undertaken to evaluate the clinical significance of alterations in S 3Ab levels. Serial samples collected from patients prior to surgery, and at 2 wk and at 2 mo were analyzed for S 3AB levels. The increase in S 3Ab titre was found to be fourfold or greater as a consequence of surgery. Patients remaining free of disease-circulating S 3Ab levels gradually decreased, patients eventually becoming seronegative. However, with persistent tumor, S 3Ab levels tended to remain elevated.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalClinical and Investigative Medicine
Issue number2-3
StatePublished - 1979
Externally publishedYes


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