A complement-fixing antigen common to human sarcomas, tentatively called S 3, has previously been described. Initial observations indicated that S 3 antibody levels rise sharply following surgical removal of tumors. A prospective study was, therefore, undertaken to evaluate the clinical significance of alterations in S 3Ab levels. Serial samples collected from patients prior to surgery, and at 2 wk and at 2 mo were analyzed for S 3AB levels. The increase in S 3Ab titre was found to be fourfold or greater as a consequence of surgery. Patients remaining free of disease-circulating S 3Ab levels gradually decreased, patients eventually becoming seronegative. However, with persistent tumor, S 3Ab levels tended to remain elevated.
|Number of pages||4|
|Journal||Clinical and Investigative Medicine|
|State||Published - 1979|