Abstract
A complement-fixing antigen common to human sarcomas, tentatively called S 3, has previously been described. Initial observations indicated that S 3 antibody levels rise sharply following surgical removal of tumors. A prospective study was, therefore, undertaken to evaluate the clinical significance of alterations in S 3Ab levels. Serial samples collected from patients prior to surgery, and at 2 wk and at 2 mo were analyzed for S 3AB levels. The increase in S 3Ab titre was found to be fourfold or greater as a consequence of surgery. Patients remaining free of disease-circulating S 3Ab levels gradually decreased, patients eventually becoming seronegative. However, with persistent tumor, S 3Ab levels tended to remain elevated.
Original language | English |
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Pages (from-to) | 89-92 |
Number of pages | 4 |
Journal | Clinical and Investigative Medicine |
Volume | 2 |
Issue number | 2-3 |
State | Published - 1979 |
Externally published | Yes |