Sapropterin dihydrochloride mixed with common foods and beverages

Elaina R. Jurecki, Amy Cunningham, John J. Mahoney, Douglas Tingley, Stanley Chung, Neil James, Jessica L. Cohen-Pfeffer

Research output: Contribution to journalArticlepeer-review


Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed in selected beverages and foods. Solubility was partial for the tablets and complete for the powder. The stability testing showed that 93% or more of active sapropterin dihydrochloride is present at 1 hour after either tablets or powders are mixed with certain foods and beverages. Mixing sapropterin powder with foods and beverages might facilitate its administration in patients who have difficulty swallowing the drug according to prescribing information.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalTopics in Clinical Nutrition
Issue number4
StatePublished - 12 Dec 2014
Externally publishedYes


  • Phenylalanine
  • Phenylketonuria
  • Sapropterin
  • Tetrahydrobiopterin


Dive into the research topics of 'Sapropterin dihydrochloride mixed with common foods and beverages'. Together they form a unique fingerprint.

Cite this