Sapropterin dihydrochloride mixed with common foods and beverages

Elaina R. Jurecki; Amy Cunningham; John J. Mahoney; Douglas Tingley; Stanley Chung; Neil James; Jessica L. Cohen-Pfeffer

doi:10.1097/TIN.0000000000000010

Sapropterin dihydrochloride mixed with common foods and beverages

Elaina R. Jurecki, Amy Cunningham, John J. Mahoney, Douglas Tingley, Stanley Chung, Neil James, Jessica L. Cohen-Pfeffer

Research output: Contribution to journal › Article › peer-review

Abstract

Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed in selected beverages and foods. Solubility was partial for the tablets and complete for the powder. The stability testing showed that 93% or more of active sapropterin dihydrochloride is present at 1 hour after either tablets or powders are mixed with certain foods and beverages. Mixing sapropterin powder with foods and beverages might facilitate its administration in patients who have difficulty swallowing the drug according to prescribing information.

Original language	English
Pages (from-to)	325-331
Number of pages	7
Journal	Topics in Clinical Nutrition
Volume	29
Issue number	4
DOIs	https://doi.org/10.1097/TIN.0000000000000010
State	Published - 12 Dec 2014
Externally published	Yes

Keywords

Phenylalanine
Phenylketonuria
Sapropterin
Tetrahydrobiopterin

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10.1097/TIN.0000000000000010

Cite this

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title = "Sapropterin dihydrochloride mixed with common foods and beverages",

abstract = "Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed in selected beverages and foods. Solubility was partial for the tablets and complete for the powder. The stability testing showed that 93% or more of active sapropterin dihydrochloride is present at 1 hour after either tablets or powders are mixed with certain foods and beverages. Mixing sapropterin powder with foods and beverages might facilitate its administration in patients who have difficulty swallowing the drug according to prescribing information.",

keywords = "Phenylalanine, Phenylketonuria, Sapropterin, Tetrahydrobiopterin",

author = "Jurecki, {Elaina R.} and Amy Cunningham and Mahoney, {John J.} and Douglas Tingley and Stanley Chung and Neil James and Cohen-Pfeffer, {Jessica L.}",

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TY - JOUR

T1 - Sapropterin dihydrochloride mixed with common foods and beverages

AU - Jurecki, Elaina R.

AU - Cunningham, Amy

AU - Mahoney, John J.

AU - Tingley, Douglas

AU - Chung, Stanley

AU - James, Neil

AU - Cohen-Pfeffer, Jessica L.

PY - 2014/12/12

Y1 - 2014/12/12

N2 - Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed in selected beverages and foods. Solubility was partial for the tablets and complete for the powder. The stability testing showed that 93% or more of active sapropterin dihydrochloride is present at 1 hour after either tablets or powders are mixed with certain foods and beverages. Mixing sapropterin powder with foods and beverages might facilitate its administration in patients who have difficulty swallowing the drug according to prescribing information.

AB - Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed in selected beverages and foods. Solubility was partial for the tablets and complete for the powder. The stability testing showed that 93% or more of active sapropterin dihydrochloride is present at 1 hour after either tablets or powders are mixed with certain foods and beverages. Mixing sapropterin powder with foods and beverages might facilitate its administration in patients who have difficulty swallowing the drug according to prescribing information.

KW - Phenylalanine

KW - Phenylketonuria

KW - Sapropterin

KW - Tetrahydrobiopterin

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DO - 10.1097/TIN.0000000000000010

M3 - Article

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VL - 29

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JO - Topics in Clinical Nutrition

JF - Topics in Clinical Nutrition

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ER -

Sapropterin dihydrochloride mixed with common foods and beverages

Abstract

Keywords

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