Salivary gland enlargement and elevated serum amylase in bulimia nervosa

Eran D. Metzger; Jeffrey M. Levine; Colin R. McArdle; Barbara E. Wolfe; David C. Jimerson

doi:10.1016/S0006-3223(98)00221-2

Salivary gland enlargement and elevated serum amylase in bulimia nervosa

Eran D. Metzger, Jeffrey M. Levine, Colin R. McArdle, Barbara E. Wolfe, David C. Jimerson

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: Clinical reports have described salivary gland enlargement in bulimia nervosa, particularly in patients with elevated serum amylase concentration. The goal of the current study was to provide a controlled comparison of salivary gland size in patients with bulimia nervosa and healthy volunteers. Methods: Subjects included 17 women with bulimia nervosa and 21 healthy female control subjects. Dimensions of the parotid and submandibular salivary glands were estimated by ultrasonography. Blood samples for amylase measurement were obtained after overnight fast. Results: Parotid gland size was enlarged 36% in patients with bulimia nervosa in comparison to control subjects (p < .01). For the patient group, salivary gland size was significantly correlated with frequency of bulimic symptoms and with serum amylase concentration. Conclusions: These results provide new quantitative data demonstrating increased salivary gland size in bulimia nervosa. Further studies are needed to evaluate factors responsible for salivary gland enlargement and hyperamylasemia in this disorder.

Original language	English
Pages (from-to)	1520-1522
Number of pages	3
Journal	Biological Psychiatry
Volume	45
Issue number	11
DOIs	https://doi.org/10.1016/S0006-3223(98)00221-2
State	Published - 1 Jun 1999
Externally published	Yes

Keywords

Amylases
Bulimia
Eating disorder
Parotid gland
Salivary glands
Ultrasonography

Access to Document

10.1016/S0006-3223(98)00221-2

Cite this

@article{458f3ff284d9431e85643c96b5c5e38c,

title = "Salivary gland enlargement and elevated serum amylase in bulimia nervosa",

abstract = "Background: Clinical reports have described salivary gland enlargement in bulimia nervosa, particularly in patients with elevated serum amylase concentration. The goal of the current study was to provide a controlled comparison of salivary gland size in patients with bulimia nervosa and healthy volunteers. Methods: Subjects included 17 women with bulimia nervosa and 21 healthy female control subjects. Dimensions of the parotid and submandibular salivary glands were estimated by ultrasonography. Blood samples for amylase measurement were obtained after overnight fast. Results: Parotid gland size was enlarged 36% in patients with bulimia nervosa in comparison to control subjects (p < .01). For the patient group, salivary gland size was significantly correlated with frequency of bulimic symptoms and with serum amylase concentration. Conclusions: These results provide new quantitative data demonstrating increased salivary gland size in bulimia nervosa. Further studies are needed to evaluate factors responsible for salivary gland enlargement and hyperamylasemia in this disorder.",

keywords = "Amylases, Bulimia, Eating disorder, Parotid gland, Salivary glands, Ultrasonography",

author = "Metzger, {Eran D.} and Levine, {Jeffrey M.} and McArdle, {Colin R.} and Wolfe, {Barbara E.} and Jimerson, {David C.}",

note = "Funding Information: Supported in part by USPHS grants K07 MH00965 (to Dr. Wolfe) from the National Institute of Mental Health, and grant RR01032 to the General Clinical Research Center at Beth Israel Deaconess Medical Center from the National Center for Research Resources, National Institutes of Health. ",

year = "1999",

month = jun,

day = "1",

doi = "10.1016/S0006-3223(98)00221-2",

language = "English",

volume = "45",

pages = "1520--1522",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Salivary gland enlargement and elevated serum amylase in bulimia nervosa

AU - Metzger, Eran D.

AU - Levine, Jeffrey M.

AU - McArdle, Colin R.

AU - Wolfe, Barbara E.

AU - Jimerson, David C.

N1 - Funding Information: Supported in part by USPHS grants K07 MH00965 (to Dr. Wolfe) from the National Institute of Mental Health, and grant RR01032 to the General Clinical Research Center at Beth Israel Deaconess Medical Center from the National Center for Research Resources, National Institutes of Health.

PY - 1999/6/1

Y1 - 1999/6/1

N2 - Background: Clinical reports have described salivary gland enlargement in bulimia nervosa, particularly in patients with elevated serum amylase concentration. The goal of the current study was to provide a controlled comparison of salivary gland size in patients with bulimia nervosa and healthy volunteers. Methods: Subjects included 17 women with bulimia nervosa and 21 healthy female control subjects. Dimensions of the parotid and submandibular salivary glands were estimated by ultrasonography. Blood samples for amylase measurement were obtained after overnight fast. Results: Parotid gland size was enlarged 36% in patients with bulimia nervosa in comparison to control subjects (p < .01). For the patient group, salivary gland size was significantly correlated with frequency of bulimic symptoms and with serum amylase concentration. Conclusions: These results provide new quantitative data demonstrating increased salivary gland size in bulimia nervosa. Further studies are needed to evaluate factors responsible for salivary gland enlargement and hyperamylasemia in this disorder.

AB - Background: Clinical reports have described salivary gland enlargement in bulimia nervosa, particularly in patients with elevated serum amylase concentration. The goal of the current study was to provide a controlled comparison of salivary gland size in patients with bulimia nervosa and healthy volunteers. Methods: Subjects included 17 women with bulimia nervosa and 21 healthy female control subjects. Dimensions of the parotid and submandibular salivary glands were estimated by ultrasonography. Blood samples for amylase measurement were obtained after overnight fast. Results: Parotid gland size was enlarged 36% in patients with bulimia nervosa in comparison to control subjects (p < .01). For the patient group, salivary gland size was significantly correlated with frequency of bulimic symptoms and with serum amylase concentration. Conclusions: These results provide new quantitative data demonstrating increased salivary gland size in bulimia nervosa. Further studies are needed to evaluate factors responsible for salivary gland enlargement and hyperamylasemia in this disorder.

KW - Amylases

KW - Bulimia

KW - Eating disorder

KW - Parotid gland

KW - Salivary glands

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=0032853237&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(98)00221-2

DO - 10.1016/S0006-3223(98)00221-2

M3 - Article

C2 - 10356637

AN - SCOPUS:0032853237

SN - 0006-3223

VL - 45

SP - 1520

EP - 1522

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 11

ER -

Salivary gland enlargement and elevated serum amylase in bulimia nervosa

Abstract

Keywords

Access to Document

Fingerprint

Cite this