Safety of selegiline with cold medications

Jeena E. Jacob, Mary L. Wagner, Jacob I. Sage, Christina Dalmady-Israel, Bruno Edouard

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


OBJECTIVE: To evaluate the safety of the coadministration of selegiline with cold medications. DATA SOURCES: Clinical literature accessed through MEDLINE(1965-September 2002), IPA database, and Drug-Reax System. The following search terms were used: selegiline, pseudoephedrine, dextromethorphan, MAOI, and drug interactions. Somerset Pharmaceuticals, the marketers of Eldepryl (selegiline HCI), were also contacted. DATA SYNTHESIS: Despite a warning against its concomitant use with pseudoephedrine and dextromethorphan, interactions with selegiline have not been reported. However, there have been reports of patients experiencing adverse events with related agents. CONCLUSIONS: Patients taking selegiline should try to avoid pseudoephedrine and dextromethorphan or use drugs without interaction potential. If selegiline is used with these medications, watch for adverse events or replace selegiline with another drug.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalAnnals of Pharmacotherapy
Issue number3
StatePublished - 1 Mar 2003
Externally publishedYes


  • Dextromethorphan
  • Parkinson disease
  • Pseudoephedrine
  • Selegiline


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