Safety of left atrial appendage closure in heart failure patients

Subrat Das, Marta Lorente-Ros, Lingling Wu, Davendra Mehta, Ranjit Suri

Research output: Contribution to journalArticlepeer-review


Introduction: Left atrial appendage closure (LAAC) is an intervention aimed at stroke prevention in nonvalvular atrial fibrillation (AF). There is a three-fold increased risk of stroke in patients with concomitant presence of AF and heart failure (HF). While anticoagulation is effective, only 60% receive it. We aimed at studying the safety of LAAC in HF patients using a national all-payer database. Methods: We queried the National Inpatient Sample for the year 2016–2018 for WATCHMAN device insertion using ICD 10 procedure codes. We divided the study population into HF and non-HF groups. Outcomes were compared using appropriate statistical tests, p<.05 was considered significant. Results: 34 385 LAAC procedures were identified of which 8530 (24.8%) were done in patients with HF. The mean (SD) age of the study population was 76 (7.9) years and 42% were female. There was no difference in mean age between HF and non-HF groups. Our findings indicate that there is no difference in inpatient mortality and cardiac complications between the HF and non-HF groups. However, noncardiac complications including acute kidney injury and respiratory failure were higher in the HF group. Conclusion: LAAC appears to be a safe procedure in patients with HF. The study is limited by a short follow up period and long-term follow-up is required before definitive conclusions can be made.

Original languageEnglish
Pages (from-to)2578-2584
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Issue number12
StatePublished - Dec 2022


  • NIS
  • heart failure
  • left atrial appendage closure
  • safety


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