Safety of Endoscopy in Heritable Connective Tissue Disorders

Saikiran M. Kilaru, Kenneth J. Mukamal, Judy W. Nee, Sveta S. Oza, Anthony J. Lembo, Jacqueline L. Wolf

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction: Little is known about the gastrointestinal manifestations or safety of endoscopy among patients with heritable connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome (EDS). Methods : We conducted an electronic cross-sectional survey nested within preexisting registries of patients with heritable connective tissue disorders and examined self-reported rates of endoscopic complications. Results : The rate of endoscopy-related perforation was 9.4% (95% confidence interval 2.0%-25.0%) among individuals with vascular EDS, <1% in classical and hypermobility-type EDS, and zero in Marfan syndrome (P < 0.001). Spontaneous intestinal perforation was also significantly higher in the vascular EDS group. DISCUSSION: Clinicians should consider noninvasive screening methods for patients with vascular EDS.

Original languageEnglish
Pages (from-to)1343-1345
Number of pages3
JournalAmerican Journal of Gastroenterology
Issue number8
StatePublished - 1 Aug 2019
Externally publishedYes


Dive into the research topics of 'Safety of Endoscopy in Heritable Connective Tissue Disorders'. Together they form a unique fingerprint.

Cite this