Safety of Endoscopy in Heritable Connective Tissue Disorders

Saikiran M. Kilaru; Kenneth J. Mukamal; Judy W. Nee; Sveta S. Oza; Anthony J. Lembo; Jacqueline L. Wolf

doi:10.14309/ajg.0000000000000189

Safety of Endoscopy in Heritable Connective Tissue Disorders

Saikiran M. Kilaru, Kenneth J. Mukamal, Judy W. Nee, Sveta S. Oza, Anthony J. Lembo, Jacqueline L. Wolf

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Introduction: Little is known about the gastrointestinal manifestations or safety of endoscopy among patients with heritable connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome (EDS). Methods : We conducted an electronic cross-sectional survey nested within preexisting registries of patients with heritable connective tissue disorders and examined self-reported rates of endoscopic complications. Results : The rate of endoscopy-related perforation was 9.4% (95% confidence interval 2.0%-25.0%) among individuals with vascular EDS, <1% in classical and hypermobility-type EDS, and zero in Marfan syndrome (P < 0.001). Spontaneous intestinal perforation was also significantly higher in the vascular EDS group. DISCUSSION: Clinicians should consider noninvasive screening methods for patients with vascular EDS.

Original language	English
Pages (from-to)	1343-1345
Number of pages	3
Journal	American Journal of Gastroenterology
Volume	114
Issue number	8
DOIs	https://doi.org/10.14309/ajg.0000000000000189
State	Published - 1 Aug 2019
Externally published	Yes

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title = "Safety of Endoscopy in Heritable Connective Tissue Disorders",

abstract = "Introduction: Little is known about the gastrointestinal manifestations or safety of endoscopy among patients with heritable connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome (EDS). Methods : We conducted an electronic cross-sectional survey nested within preexisting registries of patients with heritable connective tissue disorders and examined self-reported rates of endoscopic complications. Results : The rate of endoscopy-related perforation was 9.4% (95% confidence interval 2.0%-25.0%) among individuals with vascular EDS, <1% in classical and hypermobility-type EDS, and zero in Marfan syndrome (P < 0.001). Spontaneous intestinal perforation was also significantly higher in the vascular EDS group. DISCUSSION: Clinicians should consider noninvasive screening methods for patients with vascular EDS.",

author = "Kilaru, {Saikiran M.} and Mukamal, {Kenneth J.} and Nee, {Judy W.} and Oza, {Sveta S.} and Lembo, {Anthony J.} and Wolf, {Jacqueline L.}",

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T1 - Safety of Endoscopy in Heritable Connective Tissue Disorders

AU - Kilaru, Saikiran M.

AU - Mukamal, Kenneth J.

AU - Nee, Judy W.

AU - Oza, Sveta S.

AU - Lembo, Anthony J.

AU - Wolf, Jacqueline L.

PY - 2019/8/1

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AB - Introduction: Little is known about the gastrointestinal manifestations or safety of endoscopy among patients with heritable connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome (EDS). Methods : We conducted an electronic cross-sectional survey nested within preexisting registries of patients with heritable connective tissue disorders and examined self-reported rates of endoscopic complications. Results : The rate of endoscopy-related perforation was 9.4% (95% confidence interval 2.0%-25.0%) among individuals with vascular EDS, <1% in classical and hypermobility-type EDS, and zero in Marfan syndrome (P < 0.001). Spontaneous intestinal perforation was also significantly higher in the vascular EDS group. DISCUSSION: Clinicians should consider noninvasive screening methods for patients with vascular EDS.

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Safety of Endoscopy in Heritable Connective Tissue Disorders

Abstract

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