Safety and Efficacy of OPN Balloon in Patients With Calcified Coronary Artery Disease

Nagendra Boopathy Senguttuvan, Harsimran Singh, Balakrishnan Vinod Kumar, Rahul Chowdary Kongara, Rizwan Suliankatchi Abdulkader, Asuwin Anandaram, Preetam Krishnamurthy, Jayanthy Venkata Balasubramaniyan, Shanmugasundram Sadhanandham, Sankaran Ramesh, Panchanatham Manokar, Thoddi Ramamurthy Muralidharan, Jayanthy S.N. Murthy, Sadagopan Thanikachalam

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Patients with symptomatic calcified coronary lesions have poor outcomes. Such lesions require additional atherectomy devices for bed preparation. Aim: To assess the safety and efficacy of OPN balloon in patients with calcified coronary lesions. Methods: This is an investigator-initiated, prospective, observational study. The primary outcome of the study was a procedural success. Results: We studied 71 patients (133 lesions). Maximum lesions were located in LAD [46.6 %]. The OPN balloon was used for pre-dilatation alone in 28.6 % (Pre-stent OPN group), post-dilatation alone in 63.2 % of lesions (Post-stent OPN group), and in both situations in 8.3 % of lesions with procedural success in 98.5 % of patients. Further dilatation with different NC balloons was required in both groups (30 %). The median (IQR) OPN balloon diameter in the pre- and post-stent OPN group were 2.5 (2.5, 3.0) and 3.0 (3.0,3.0) mm (p = 0.001), respectively. The difference between the diameter of the stent and OPN balloon used in pre-stent OPN group was 0.5 (0.2, 0.5) mm while it was 0.0 (0.0,0.2) mm in the post-stent OPN group (p < 0.001). Eight complications and two deaths occured. Distal shaft rupture was also noticed. Conclusion: OPN balloon is safe, and effective in treating calcified coronary lesions. We propose to undersize the balloon by 0.5 mm for pre-dilatation followed by 0.25 mm larger NC balloon if needed. In the post-dilatation group, use a 1:1 size balloon in a non-tortuous straight segment. Use imaging especially when (1) the pressure taken more than the rated burst pressure, (2) an OPN balloon size is ≥3 mm (3) using 1:1 size OPN balloon in a tortuous segment.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalCardiovascular Revascularization Medicine
Volume54
DOIs
StatePublished - Sep 2023
Externally publishedYes

Keywords

  • CAD
  • Calcified lesions
  • OPN balloon
  • Stent expansion

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