Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Luis Ortega-Paz, Mattia Galli, Davide Capodanno, Francesco Franchi, Fabiana Rollini, Behnood Bikdeli, Roxana Mehran, Gilles Montalescot, C. Michael Gibson, Renato D. Lopes, Felicita Andreotti, Dominick J. Angiolillo

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Background The clinical impact of different prophylactic anticoagulation regimens among hospitalized patients with coronavirus disease 2019 (COVID-19) remains unclear. We pooled evidence from available randomized controlled trials (RCTs) to provide insights on this topic. Methods and We searched for RCTs comparing treatment with an escalated-dose (intermediate-dose or therapeutic-dose) vs. a results standard-dose prophylactic anticoagulation regimen in critically and non-critically ill COVID-19 patients requiring hospitalization and without a formal indication for anticoagulation. The primary efficacy endpoint was all-cause death, and the primary safety endpoint was major bleeding. Seven RCTs were identified, including 5154 patients followed on an average of 33 days. Compared to standard-dose prophylactic anticoagulation, escalated-dose prophylactic anticoagulation was not associated with a reduction of all-cause death [17.8% vs. 18.6%; risk ratio (RR) 0.96, 95% confidence interval (CI) 0.78-1.18] but was associated with an increase in major bleeding (2.4% vs. 1.4%; RR 1.73, 95%CI 1.15-2.60). Compared to prophylactic anticoagulation used at a standard dose, an escalated dose was associated with lower rates of venous thromboembolism (2.5% vs. 4.7%; RR 0.55, 95%CI 0.41-0.74) without a significant effect on myocardial infarction (RR 0.80, 95%CI 0.47-1.36), stroke (RR 0.94, 95%CI 0.43-2.09), or systemic arterial embolism (RR 1.20, 95%CI 0.29-4.95). There were no significant interactions in the subgroup analysis for critically and non-critically ill patients. Conclusions Our findings provide comprehensive and high-quality evidence for the use of standard-dose prophylactic anticoagulation over an escalated-dose regimen as routine standard of care for hospitalized patients with COVID-19 who do not have an indication for therapeutic anticoagulation, irrespective of disease severity.

Original languageEnglish
Pages (from-to)677-686
Number of pages10
JournalEuropean Heart Journal - Cardiovascular Pharmacotherapy
Volume8
Issue number7
DOIs
StatePublished - 1 Nov 2022

Keywords

  • Anticoagulant therapy
  • Bleeding
  • Coronavirus disease 2019
  • Death
  • Thrombosis

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