Safe harbours for the integration of new DNA in the human genome

Michel Sadelain, Eirini P. Papapetrou, Frederic D. Bushman

Research output: Contribution to journalReview articlepeer-review

354 Scopus citations

Abstract

DNA and the host genome limit the reliability and safety of transgene integration for therapeutic cell engineering and other applications. Although targeted gene delivery has made considerable progress, the question of where to insert foreign sequences in the human genome to maximize safety and efficacy has received little attention. In this Opinion article, we discuss 'genomic safe harbours'-chromosomal locations where therapeutic transgenes can integrate and function in a predictable manner without perturbing endogenous gene activity and promoting cancer.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalNature Reviews Cancer
Volume12
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

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