S1P signaling and de novo biosynthesis in blood pressure homeostasis

Anna Cantalupo, Annarita Di Lorenzo

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed.

Original languageEnglish
Pages (from-to)359-370
Number of pages12
JournalJournal of Pharmacology and Experimental Therapeutics
Volume358
Issue number2
DOIs
StatePublished - Aug 2016
Externally publishedYes

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