S-adenosyl-L-methionine analogues to enhance the production of actinorhodin

Youhoon Chong; Jungmo Young; Jinyoung Kim; Yukyung Lee; Kwang Su Park; Jun Ho Cho; Hyung Jin Kwon; Joo Won Suh; Yoongho Lim

S-adenosyl-L-methionine analogues to enhance the production of actinorhodin

Youhoon Chong, Jungmo Young, Jinyoung Kim, Yukyung Lee, Kwang Su Park, Jun Ho Cho, Hyung Jin Kwon, Joo Won Suh, Yoongho Lim

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.

Original language	English
Pages (from-to)	1154-1157
Number of pages	4
Journal	Journal of Microbiology and Biotechnology
Volume	16
Issue number	7
State	Published - Jul 2006
Externally published	Yes

Keywords

Actinorhodin
S-adenosyl-L-homocysteine
S-adenosyl-L-methionine
Streptomyces coelicolor

Cite this

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title = "S-adenosyl-L-methionine analogues to enhance the production of actinorhodin",

abstract = "It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.",

keywords = "Actinorhodin, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, Streptomyces coelicolor",

author = "Youhoon Chong and Jungmo Young and Jinyoung Kim and Yukyung Lee and Park, {Kwang Su} and Cho, {Jun Ho} and Kwon, {Hyung Jin} and Suh, {Joo Won} and Yoongho Lim",

year = "2006",

month = jul,

language = "English",

volume = "16",

pages = "1154--1157",

journal = "Journal of Microbiology and Biotechnology",

issn = "1017-7825",

publisher = "Korean Society for Microbiolog and Biotechnology",

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T1 - S-adenosyl-L-methionine analogues to enhance the production of actinorhodin

AU - Chong, Youhoon

AU - Young, Jungmo

AU - Kim, Jinyoung

AU - Lee, Yukyung

AU - Park, Kwang Su

AU - Cho, Jun Ho

AU - Kwon, Hyung Jin

AU - Suh, Joo Won

AU - Lim, Yoongho

PY - 2006/7

Y1 - 2006/7

N2 - It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.

AB - It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.

KW - Actinorhodin

KW - S-adenosyl-L-homocysteine

KW - S-adenosyl-L-methionine

KW - Streptomyces coelicolor

UR - http://www.scopus.com/inward/record.url?scp=33746893735&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33746893735

SN - 1017-7825

VL - 16

SP - 1154

EP - 1157

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 7

ER -

S-adenosyl-L-methionine analogues to enhance the production of actinorhodin

Abstract

Keywords

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