Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.

Original languageEnglish
Pages (from-to)540-541
Number of pages2
JournalCell Metabolism
Issue number4
StatePublished - 6 Oct 2015


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