Running on empty: Leptin signaling in VTA regulates reward from physical activity

Zuxin Chen; Paul J. Kenny

doi:10.1016/j.cmet.2015.09.021

Running on empty: Leptin signaling in VTA regulates reward from physical activity

Zuxin Chen, Paul J. Kenny

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.

Original language	English
Pages (from-to)	540-541
Number of pages	2
Journal	Cell Metabolism
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2015.09.021
State	Published - 6 Oct 2015

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title = "Running on empty: Leptin signaling in VTA regulates reward from physical activity",

abstract = "Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the {"}high{"} experienced by endurance runners.",

author = "Zuxin Chen and Kenny, {Paul J.}",

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year = "2015",

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T1 - Running on empty

T2 - Leptin signaling in VTA regulates reward from physical activity

AU - Chen, Zuxin

AU - Kenny, Paul J.

PY - 2015/10/6

Y1 - 2015/10/6

N2 - Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.

AB - Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.

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U2 - 10.1016/j.cmet.2015.09.021

DO - 10.1016/j.cmet.2015.09.021

M3 - Short survey

C2 - 26445509

AN - SCOPUS:84943410790

SN - 1550-4131

VL - 22

SP - 540

EP - 541

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Running on empty: Leptin signaling in VTA regulates reward from physical activity

Abstract

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