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Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning
Alice H. Reis,
Sergei Y. Sokol
Icahn School of Medicine at Mount Sinai
Cancer Mechanisms
Cell, Developmental, and Regenerative Biology
Friedman Brain Institute
Graduate School of Biomedical Sciences
The Tisch Cancer Institute
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Keyphrases
Vertebrates
100%
RSPO2
100%
FGF Signaling
100%
Mesoderm Patterning
100%
Mesoderm Formation
100%
MEK1
25%
Wnt Signaling
25%
ERK1
25%
R-spondin
25%
Active Form
12%
Thrombospondin-1 (TSP-1)
12%
Embryonic Development
12%
Constitutively Active
12%
Secreted Proteins
12%
Wnt Signaling Pathway
12%
Inhibitory Activity
12%
Ectoderm
12%
Xenopus
12%
Intramolecular Interactions
12%
Furin
12%
Novel Functions
12%
Signal Process
12%
Brachyury
12%
Developmental Signaling Pathways
12%
Pathway Regulation
12%
Axis Specification
12%
Domain Analysis
12%
Cdx4
12%
Biochemistry, Genetics and Molecular Biology
Wnt Signaling Pathway
100%
Mesoderm
100%
Explant
66%
Embryogenesis
33%
Downregulation
33%
Xenopus
33%
Epiblast
33%
Thrombospondin
33%
Furin
33%
Ectoderm
33%
Brachyury
33%