Roles of RUNX in Hippo pathway signaling

Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol, Megan Finch-Edmondson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

26 Scopus citations

Abstract

The Runt-domain (RD) transcription factors (RUNX genes) are an important family of transcriptional mediators that interact with a variety of proteins including the Hippo pathway effector proteins, YAP and TAZ. In this chapter we focus on two examples of RUNX-TAZ/YAP interactions that have particular significance in human cancer. Specifically, recent evidence has found that RUNX2 cooperates with TAZ to promote epithelial to mesenchymal transition mediated by the soluble N-terminal ectodomain of E-Cadherin, sE-Cad. Contrastingly, in gastric cancer, RUNX3 acts as a tumor suppressor via inhibition of the YAP-TEAD complex and disruption of downstream YAP-mediated gene transcription and the oncogenic phenotype. The reports highlighted in this chapter add to the growing repertoire of instances of Hippo pathway crosstalk that have been identified in cancer. Elucidation of these increasingly complex interactions may help to identify novel strategies to target Hippo pathway dysregulation in human cancer.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages435-448
Number of pages14
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume962
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Breast cancer
  • Gastric cancer
  • Hippo pathway
  • RUNX proteins
  • TAZ
  • TEAD
  • YAP
  • sE-Cad

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