Roles of biogenic amines in intestinal signaling

Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of biogenic amines can induce adverse reactions and are harmful to animal’s health. Therefore, it is crucial to have a clear understanding of how different biogenic amines interact with a body’s intestinal function signaling pathways and to monitor the content of biogenic amines in the gastrointestinal tract. And in turn, the proper concentration of dietary protein and balanced amino acids for humans and livestock could be given. Though numerous methods have been developed and improved for the detection of biogenic amines in foods or wines, much less attention has been paid directly to the determination of amine levels in the gastrointestinal tract. In this article, we mainly focus on the interaction of amines with the intestinal function signaling pathway and the broad impacts on animal physiology, and our modified method to accurately and quickly detect the biogenic amines in the digesta of an animal intestine.