TY - JOUR
T1 - Role of toll-like receptor 4 in the proinflammatory response to Vibrio cholerae O1 El Tor strains deficient in production of cholera toxin and accessory toxins
AU - Haines, G. Kenneth
AU - Sayed, Blayne Amir
AU - Rohrer, Melissa S.
AU - Olivier, Verena
AU - Satchell, Karla J.Fullner
PY - 2005/9
Y1 - 2005/9
N2 - Following intranasal inoculation, Vibrio cholerae KFV101 (ΔctxAB ΔhapA ΔhlyA Δrtx4) colonizes and stimulates tumor necrosis factor alpha and interleukin 1β (IL-1β) in mice, similar to what occurs with isogenic strain P4 (ΔctxAB), but is less virulent and stimulates reduced levels of IL-6, demonstrating a role for accessory toxins in pathogenesis. Morbidity is enhanced in C3H/HeJ mice, indicating that Toll-like receptor 4 is important for infection containment.
AB - Following intranasal inoculation, Vibrio cholerae KFV101 (ΔctxAB ΔhapA ΔhlyA Δrtx4) colonizes and stimulates tumor necrosis factor alpha and interleukin 1β (IL-1β) in mice, similar to what occurs with isogenic strain P4 (ΔctxAB), but is less virulent and stimulates reduced levels of IL-6, demonstrating a role for accessory toxins in pathogenesis. Morbidity is enhanced in C3H/HeJ mice, indicating that Toll-like receptor 4 is important for infection containment.
UR - http://www.scopus.com/inward/record.url?scp=23944442815&partnerID=8YFLogxK
U2 - 10.1128/IAI.73.9.6157-6164.2005
DO - 10.1128/IAI.73.9.6157-6164.2005
M3 - Article
C2 - 16113340
AN - SCOPUS:23944442815
SN - 0019-9567
VL - 73
SP - 6157
EP - 6164
JO - Infection and Immunity
JF - Infection and Immunity
IS - 9
ER -