Role of thrombopoietin in mast cell differentiation

Anna Rita Migliaccio, Rosa Alba Rana, Alessandro M. Vannucchi, Francesco A. Manzoli

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

9 Scopus citations


Mast cells are important elements of the body response to foreign antigens, being those represented either by small molecules (allergic response) or harbored by foreign microorganisms (response to parasite infection). These cells derive from hematopoietic stem/progenitor cells present in the marrow. However, in contrast with most of the other hematopoietic lineages, mast cells do not differentiate in the marrow but in highly vascularized extramedullary sites, such as the skin or the gut. Mast cell differentiation in the marrow is activated as part of the body response to parasites. We will review here the mast cell differentiation pathway and what is known of its major intrinsic and extrinsic control mechanisms. It will also be described that thrombopoietin, the ligand for the Mpl receptor, in addition to its pivotal rule in the control of thrombocytopoiesis and of hematopoietic stem/progenitor cell proliferation, exerts a regulatory function in mast cell differentiation. Some of the possible implications of this newly described biological activity of thrombopoietin will be discussed.

Original languageEnglish
Title of host publicationHematopoietic Stem Cells VI
PublisherBlackwell Publishing Inc.
Number of pages23
ISBN (Print)1573316768, 9781573316767
StatePublished - Jun 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Apoptosis
  • Gata1
  • Mast cells
  • Mpl
  • Thrombopoietin


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