@article{2e9055bf4ca14b5c9404911684bb3f69,
title = "Role of the otolith organs in generation of horizontal nystagmus: effects of selective labyrinthine lesions",
abstract = "Selective labyrinthine lesions were made to study the origin of excitation in the labyrinth during off-vertical axis rotation. Plugging the semicircular canals abolishes the response to rotation about a vertical axis, but optokinetic after-nystagmus (OKAN) and the sustained horizontal nystagmus induced by off-vertical axis rotation (OVAR) are maintained. After cutting the nerves of the lateral semicircular canals, neither horizontal OKAN nor the continuous horizontal nystagmus associated with off-axis rotation can be induced, although vertical OKN, OKAN and vestibular nystagmus are intact. This supports the theory that labyrinthine activity responsible for the nystagmus induced by OVAR arises in the otolith organs and couples to the oculomotor system through the velocity storage mechanism.",
keywords = "labyrinth, nystagmus, otolith organs, semicircular canals, velocity storage, vestibulo-ocular reflex",
author = "Bernard Cohen and Suzuki, \{Jun Ichi\} and Theodore Raphan",
note = "Funding Information: 1 Benson, A. J. and Bodin, M. A., Interaction of linear and angular accelerations on vestibular receptors in man, Aero-space Med., 37 (1966) 144-154. 2 Benson, A. J., Guedry, F. E. and Melvill Jones, G., Re-sponse of semicircular canal dependent units in vestibular nuclei to rotation of a linear acceleration vector without an-gular acceleration, J. Physiol. (Lond.), 210 (1970) 475-494. 3 Brandt, Th., Dichgans, J. and Biichele, W., Motion habit-uation: inverted self-motion perception and optokinetic af-ter-nystagmus, Exp. Brain Res., 21 (1974) 337-352. 4 Cohen, B., Matsuo, V. and Raphan, T., Quantitative anal-ysis of the velocity characteristics of optokinetic nystagmus and optokinetic after-nystagmus, J. Physiol. (Lond.), (1974) 321-344. 5 Cohen, B., Uemura, T. and Takamori, S., Effects of lab-yrinthectomy on optokinetic nystagmus (OKN) and optoki-netic after-nystagmus (OKAN), Equil. Res., 3 (1973) 88-93. 6 Correia, M. J. and Money, K. E., The effect of all six semi-circular canal ducts on nystagmus produced by linear acce-leration in the cat, Acta Otolaryngol., 69 (1970) 7-16. 7 Ewald, J. R., Physiologische Untersuchungen iiber das En-dorgan des Nervus Octavus, Bergmann, Wiesbaden, 1892. 8 Guedry, F. E., Orientation of the rotation axis relative to gravity: its influence on nystagmus and the sense of rota-tion, Acta Otolaryngol., 60 (1965) 30-48. 9 Igarashi, M., Takahashi, M., Kubo, T., Alford, B. R. and Wright, W. K., Effect of off-vertical tilt and macular abla-tion on post-rotatory nystagmus in the squirrel monkey, Acta Otolaryngol., 90 (1980) 93-99. 10 Janeke, J. B., Jongkees, L. B. and Oosterveld, W. J., Relationship between otoliths and nystagmus, Acta Otola- Supported by NIH Research Grant NS 00294, Core Center Grant EY 01867 and a grant from the Young Men's Philanthropic League. T.R. was supported by an Academic Investigator Award (EY",
year = "1983",
month = oct,
day = "3",
doi = "10.1016/0006-8993(83)90558-9",
language = "English",
volume = "276",
pages = "159--164",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}