TY - CHAP
T1 - Role of the Microbiome in Polyphenol Metabolite-Mediated Attenuation of β-amyloid and tau Protein Misfolding in Alzheimer’s Disease
AU - Wang, Jun
AU - Ho, Lap
AU - Faith, Jeremiah
AU - Ono, Kenjiro
AU - Księżak-Reding, Hanna
AU - Sharma, Ali
AU - Valcarcel, Breanna
AU - Pasinetti, Giulio M.
N1 - Publisher Copyright:
© 2018 by World Scientific Publishing Co. Pte. Ltd.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Alzheimer’s disease (AD) is one of the top public health challenges facing the Western world and developing countries due to ever-increasing aging population [1]. There is, however, no effective means to prevent or to treat AD. There have been more than 100 drug trials targeting specific AD pathogenic mechanisms since 1998, all of which have failed [2]. Since AD is a complex disease involving multiple interrelating pathogenic mechanisms, redirecting therapeutic strategies to simultaneously target multiple pathogenic mechanisms may increase the likelihood of success.
AB - Alzheimer’s disease (AD) is one of the top public health challenges facing the Western world and developing countries due to ever-increasing aging population [1]. There is, however, no effective means to prevent or to treat AD. There have been more than 100 drug trials targeting specific AD pathogenic mechanisms since 1998, all of which have failed [2]. Since AD is a complex disease involving multiple interrelating pathogenic mechanisms, redirecting therapeutic strategies to simultaneously target multiple pathogenic mechanisms may increase the likelihood of success.
UR - http://www.scopus.com/inward/record.url?scp=85127155994&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:85127155994
SP - 281
EP - 304
BT - Protein Folding Disorders of the Central Nervous System
PB - World Scientific Publishing Co.
ER -