Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation

D. Dombrowicz, S. Nutten, P. Desreumaux, C. Neut, G. Torpier, M. Peeters, J. F. Colombel, M. Capron

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A role for immunoglobulin E and its high affinity receptor (FcεRI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized FcεRI (hFcεRI), with a cell distribution similar to that in humans, to FcεRI-deficient animals. In hFcεRI transgenic mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly modified, and bacterial translocation towards mesenteric lymph nodes was increased. In hFcεRI transgenic mice, 2,4,6-tri-nitrobenzenesulfonic acid (TNBS)-induced colitis was also more pronounced, whereas FcεRI-deficient animals were protected from colitis, demonstrating that FcεRI can affect the onset of intestinal inflammation.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalJournal of Experimental Medicine
Volume193
Issue number1
DOIs
StatePublished - 1 Jan 2001
Externally publishedYes

Keywords

  • Bacterial translocation
  • Colitis
  • Immunoglobulin E receptor
  • Inflammatory bowel disease
  • Intestinal permeability

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