Role of the Complement Pathway in Inflammatory Skin Diseases: A Focus on Hidradenitis Suppurativa

Mondana H. Ghias; Michael J. Hyde; Lewis E. Tomalin; B. Paul Morgan; Afsaneh Alavi; Michelle A. Lowes; Vincent Piguet

doi:10.1016/j.jid.2019.09.009

Role of the Complement Pathway in Inflammatory Skin Diseases: A Focus on Hidradenitis Suppurativa

Mondana H. Ghias
, Michael J. Hyde
, Lewis E. Tomalin
, B. Paul Morgan
, Afsaneh Alavi
, Michelle A. Lowes
, Vincent Piguet

Population Health Science and Policy

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.

Original language	English
Pages (from-to)	531-536.e1
Journal	Journal of Investigative Dermatology
Volume	140
Issue number	3
DOIs	https://doi.org/10.1016/j.jid.2019.09.009
State	Published - Mar 2020

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@article{ce33cec6138546a78164e89faffaa0ab,

title = "Role of the Complement Pathway in Inflammatory Skin Diseases: A Focus on Hidradenitis Suppurativa",

abstract = "Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.",

author = "Ghias, \{Mondana H.\} and Hyde, \{Michael J.\} and Tomalin, \{Lewis E.\} and Morgan, \{B. Paul\} and Afsaneh Alavi and Lowes, \{Michelle A.\} and Vincent Piguet",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2020",

month = mar,

doi = "10.1016/j.jid.2019.09.009",

language = "English",

volume = "140",

pages = "531--536.e1",

journal = "Journal of Investigative Dermatology",

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}

TY - JOUR

T1 - Role of the Complement Pathway in Inflammatory Skin Diseases

T2 - A Focus on Hidradenitis Suppurativa

AU - Ghias, Mondana H.

AU - Hyde, Michael J.

AU - Tomalin, Lewis E.

AU - Morgan, B. Paul

AU - Alavi, Afsaneh

AU - Lowes, Michelle A.

AU - Piguet, Vincent

PY - 2020/3

Y1 - 2020/3

N2 - Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.

AB - Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.

UR - https://www.scopus.com/pages/publications/85076849844

U2 - 10.1016/j.jid.2019.09.009

DO - 10.1016/j.jid.2019.09.009

M3 - Review article

C2 - 31870626

AN - SCOPUS:85076849844

SN - 0022-202X

VL - 140

SP - 531-536.e1

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 3

ER -

Role of the Complement Pathway in Inflammatory Skin Diseases: A Focus on Hidradenitis Suppurativa

Abstract

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