TY - JOUR
T1 - Role of the Complement Pathway in Inflammatory Skin Diseases
T2 - A Focus on Hidradenitis Suppurativa
AU - Ghias, Mondana H.
AU - Hyde, Michael J.
AU - Tomalin, Lewis E.
AU - Morgan, B. Paul
AU - Alavi, Afsaneh
AU - Lowes, Michelle A.
AU - Piguet, Vincent
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2020/3
Y1 - 2020/3
N2 - Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.
AB - Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.
UR - http://www.scopus.com/inward/record.url?scp=85076849844&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2019.09.009
DO - 10.1016/j.jid.2019.09.009
M3 - Review article
C2 - 31870626
AN - SCOPUS:85076849844
SN - 0022-202X
VL - 140
SP - 531-536.e1
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 3
ER -