Role of the β-amyloid precursor protein in Alzheimer's disease

Frank Ashall, Alison M. Goate

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Deposition of β-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the β-amyloid precursor protein (APP), which gives rise to β-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease - a prerequisite for rational drug development.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalTrends in Biochemical Sciences
Volume19
Issue number1
DOIs
StatePublished - Jan 1994
Externally publishedYes

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