Role of testosterone in managing advanced prostate cancer

Kyle O. Rove, Frans M. Debruyne, Bob Djavan, Leonard G. Gomella, Hari K. Koul, M. Scott Lucia, Daniel P. Petrylak, Neal D. Shore, Nelson N. Stone, E. David Crawford

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Androgen deprivation therapy is frequently used to treat patients with advanced prostate cancer. New therapies for metastatic castration-resistant prostate cancer have drawn increased attention to serum and intratumoral testosterone levels. The present review examines the role of testosterone in prostate cancer progression, discusses the nuances and potential pitfalls in measuring serum testosterone using available assays, and summarizes current data relevant to the arguments for and against achieving and maintaining the lowest possible testosterone levels during androgen deprivation therapy, including the adverse effects of such treatment. Incorporating this information, we have made recommendations incorporating testosterone evaluation and its effect on the clinical decision-making process.

Original languageEnglish
Pages (from-to)754-762
Number of pages9
JournalUrology
Volume80
Issue number4
DOIs
StatePublished - Oct 2012
Externally publishedYes

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