Role of repeated F-18 fluorodeoxyglucose imaging in management of patients with bone and soft tissue sarcoma

Hossam El-Zeftawy, Sherif I. Heiba, Suman Jana, Gerald Rosen, Shahenda Salem, Jonas F. Santiago, Hussein M. Abdel-Dayem

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Aim of the study: To assess the impact of repeated F-18 FDG studies on the management of patients with bone and soft tissue (B & S) sarcomas. Material and Methods: Twenty patients with B & S tissue tumors (11 M and 9 F age 17-72 years) had 52 F-18 FDG Dual Head Coincidence Imaging (DHCI) studies. 7 patients were followed for 6 months to 2 years clinically after removal of the primary tumor. Thirteen patients were evaluated for suspected recurrences. Patient's preparation F-18 FDG injection and imaging procedure were done according to department protocol. Attenuation corrected images were interpreted visually by 3 trained physicians. Tumor to background ratios were calculated for all lesions. Results: In 13 patients having both studies baseline FDG and CT/MRI were concordant in 8 patients FDG detected more lesions in 3 patients but it did not detect 4 metastatic pulmonary nodules in 2 patients. Follow up studies showed stable disease in 10 patients while 6 patients who showed worsening disease needed to change their chemotherapy. Surgery was avoided in 2 patients and 2 patients showed improved response. Conclusion: Repeated F-18 FDG DHCI examinations proved to have an impact on the clinical management of patients with malignant bone and soft tissue sarcoma. It helps to differentiate postoperative changes from local recurrence.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalCancer Biotherapy and Radiopharmaceuticals
Volume16
Issue number1
DOIs
StatePublished - Feb 2001
Externally publishedYes

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