Role of Purinergic Signaling in Voiding Dysfunction

Yan Sun, Toby C. Chai

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Purinergic signaling is a term that relates to adenosine triphosphate binding to its receptor (purinergic receptors such as P2X and P2Y subtypes). This pathway has been implicated in bladder functional disorders related to interstitial cystitis/painful bladder syndrome, neurogenic bladder secondary to spinal cord injury, lower urinary tract symptoms, diabetes, and aging. Purinergic signaling occurs at multiple sites, including the central nervous system, peripheral motor and sensory nerves, detrusor smooth muscle, and bladder urothelium. Future pharmacologic agents to treat bladder functional disorders may be able to target purinergic signaling at one or more of these sites.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalCurrent Bladder Dysfunction Reports
Issue number4
StatePublished - 2010
Externally publishedYes


  • ATP
  • Bladder physiology
  • Purinergic
  • Purinoceptors
  • Voiding dysfunction


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