Role of Pelvic Lymph Node Dissection for Clinically Localized Prostate Cancer

Yuval Elkun; Raghav Gupta; Murilo De Almeida Luz; Ashutosh K. Tewari

doi:10.1016/j.ucl.2026.02.004

Role of Pelvic Lymph Node Dissection for Clinically Localized Prostate Cancer

Yuval Elkun
, Raghav Gupta
, Murilo De Almeida Luz
, Ashutosh K. Tewari

Research output: Contribution to journal › Review article › peer-review

Abstract

The role of pelvic lymph node dissection (PLND) at the time of radical prostatectomy for clinically localized prostate cancer has remained controversial. While providing the most accurate staging for prostate cancer, the data regarding the therapeutic benefits of a PLND is inconclusive. In this article, we summarize the different PLND templates as well as the data both for and against performing a PLND. Finally, we outline future directions in selecting patients for PLND, and propose a theory on how pelvic lymph nodes may play a vital role in developing novel immunotherapy regimens.

Original language	English
Pages (from-to)	217-224
Number of pages	8
Journal	Urologic Clinics of North America
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/j.ucl.2026.02.004
State	Published - May 2026

Keywords

Biochemical recurrence
Imaging
Immunotherapy
Lymph nodes
Metastases
Prostate cancer
Staging

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@article{2074d3be83df432390a85b82b681a306,

title = "Role of Pelvic Lymph Node Dissection for Clinically Localized Prostate Cancer",

abstract = "The role of pelvic lymph node dissection (PLND) at the time of radical prostatectomy for clinically localized prostate cancer has remained controversial. While providing the most accurate staging for prostate cancer, the data regarding the therapeutic benefits of a PLND is inconclusive. In this article, we summarize the different PLND templates as well as the data both for and against performing a PLND. Finally, we outline future directions in selecting patients for PLND, and propose a theory on how pelvic lymph nodes may play a vital role in developing novel immunotherapy regimens.",

keywords = "Biochemical recurrence, Imaging, Immunotherapy, Lymph nodes, Metastases, Prostate cancer, Staging",

author = "Yuval Elkun and Raghav Gupta and \{De Almeida Luz\}, Murilo and Tewari, \{Ashutosh K.\}",

note = "Publisher Copyright: {\textcopyright} 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",

year = "2026",

month = may,

doi = "10.1016/j.ucl.2026.02.004",

language = "English",

volume = "53",

pages = "217--224",

journal = "Urologic Clinics of North America",

issn = "0094-0143",

publisher = "W.B. Saunders",

number = "2",

}

TY - JOUR

T1 - Role of Pelvic Lymph Node Dissection for Clinically Localized Prostate Cancer

AU - Elkun, Yuval

AU - Gupta, Raghav

AU - De Almeida Luz, Murilo

AU - Tewari, Ashutosh K.

PY - 2026/5

Y1 - 2026/5

N2 - The role of pelvic lymph node dissection (PLND) at the time of radical prostatectomy for clinically localized prostate cancer has remained controversial. While providing the most accurate staging for prostate cancer, the data regarding the therapeutic benefits of a PLND is inconclusive. In this article, we summarize the different PLND templates as well as the data both for and against performing a PLND. Finally, we outline future directions in selecting patients for PLND, and propose a theory on how pelvic lymph nodes may play a vital role in developing novel immunotherapy regimens.

AB - The role of pelvic lymph node dissection (PLND) at the time of radical prostatectomy for clinically localized prostate cancer has remained controversial. While providing the most accurate staging for prostate cancer, the data regarding the therapeutic benefits of a PLND is inconclusive. In this article, we summarize the different PLND templates as well as the data both for and against performing a PLND. Finally, we outline future directions in selecting patients for PLND, and propose a theory on how pelvic lymph nodes may play a vital role in developing novel immunotherapy regimens.

KW - Biochemical recurrence

KW - Imaging

KW - Immunotherapy

KW - Lymph nodes

KW - Metastases

KW - Prostate cancer

KW - Staging

UR - https://www.scopus.com/pages/publications/105034633270

U2 - 10.1016/j.ucl.2026.02.004

DO - 10.1016/j.ucl.2026.02.004

M3 - Review article

AN - SCOPUS:105034633270

SN - 0094-0143

VL - 53

SP - 217

EP - 224

JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

IS - 2

ER -

Role of Pelvic Lymph Node Dissection for Clinically Localized Prostate Cancer

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Keywords

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