Role of PACAP in the physiology and pathology of the sympathoadrenal system

Hafida Ghzili; Luca Grumolato; Erwan Thouënnon; Yannick Tanguy; Valérie Turquier; Hubert Vaudry; Youssef Anouar

doi:10.1016/j.yfrne.2007.10.001

Role of PACAP in the physiology and pathology of the sympathoadrenal system

Hafida Ghzili, Luca Grumolato, Erwan Thouënnon, Yannick Tanguy, Valérie Turquier, Hubert Vaudry, Youssef Anouar

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Sympathetic neurons and chromaffin cells derive from common sympathoadrenal precursors which arise from the neural crest. Cells from this lineage migrate to their final destination and differentiate by acquiring a catecholaminergic phenotype in response to different environmental factors. It has been shown that the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its PAC1 receptor are expressed at early stages of sympathetic development, and participate to the control of neuroblast proliferation and differentiation. PACAP also acts as a neurotransmitter to stimulate catecholamine and neuropeptide biosynthesis and release from sympathetic neurons and chromaffin cells, during development and in adulthood. In addition, PACAP and its receptors have been described in neuroblastoma and pheochromocytoma, and the neuropeptide regulates the differentiation and activity of sympathoadrenal-derived tumoral cell lines, suggestive of an important role in the pathophysiology of the sympathoadrenal lineage. Transcriptome studies uncovered genes and pathways of known and unknown roles that underlie the effects of PACAP in the sympathoadrenal system.

Original language	English
Pages (from-to)	128-141
Number of pages	14
Journal	Frontiers in Neuroendocrinology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.yfrne.2007.10.001
State	Published - Jan 2008
Externally published	Yes

Keywords

Catecholamines
Chromaffin cells
Differentiation
Neuroblastoma
Neuropeptides
PACAP
Pheochromocytoma
Sympathetic neurons
Transcriptome

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10.1016/j.yfrne.2007.10.001

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title = "Role of PACAP in the physiology and pathology of the sympathoadrenal system",

abstract = "Sympathetic neurons and chromaffin cells derive from common sympathoadrenal precursors which arise from the neural crest. Cells from this lineage migrate to their final destination and differentiate by acquiring a catecholaminergic phenotype in response to different environmental factors. It has been shown that the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its PAC1 receptor are expressed at early stages of sympathetic development, and participate to the control of neuroblast proliferation and differentiation. PACAP also acts as a neurotransmitter to stimulate catecholamine and neuropeptide biosynthesis and release from sympathetic neurons and chromaffin cells, during development and in adulthood. In addition, PACAP and its receptors have been described in neuroblastoma and pheochromocytoma, and the neuropeptide regulates the differentiation and activity of sympathoadrenal-derived tumoral cell lines, suggestive of an important role in the pathophysiology of the sympathoadrenal lineage. Transcriptome studies uncovered genes and pathways of known and unknown roles that underlie the effects of PACAP in the sympathoadrenal system.",

keywords = "Catecholamines, Chromaffin cells, Differentiation, Neuroblastoma, Neuropeptides, PACAP, Pheochromocytoma, Sympathetic neurons, Transcriptome",

author = "Hafida Ghzili and Luca Grumolato and Erwan Thou{\"e}nnon and Yannick Tanguy and Val{\'e}rie Turquier and Hubert Vaudry and Youssef Anouar",

note = "Funding Information: H.G. and E.T. were the recipients of fellowships from the Ministry of Research. Works by authors was supported by INSERM (U413), the Conseil Regional de Haute-Normandie and the COMETE network (PHRC AOM 02068).",

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doi = "10.1016/j.yfrne.2007.10.001",

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AU - Ghzili, Hafida

AU - Grumolato, Luca

AU - Thouënnon, Erwan

AU - Tanguy, Yannick

AU - Turquier, Valérie

AU - Vaudry, Hubert

AU - Anouar, Youssef

N1 - Funding Information: H.G. and E.T. were the recipients of fellowships from the Ministry of Research. Works by authors was supported by INSERM (U413), the Conseil Regional de Haute-Normandie and the COMETE network (PHRC AOM 02068).

PY - 2008/1

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N2 - Sympathetic neurons and chromaffin cells derive from common sympathoadrenal precursors which arise from the neural crest. Cells from this lineage migrate to their final destination and differentiate by acquiring a catecholaminergic phenotype in response to different environmental factors. It has been shown that the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its PAC1 receptor are expressed at early stages of sympathetic development, and participate to the control of neuroblast proliferation and differentiation. PACAP also acts as a neurotransmitter to stimulate catecholamine and neuropeptide biosynthesis and release from sympathetic neurons and chromaffin cells, during development and in adulthood. In addition, PACAP and its receptors have been described in neuroblastoma and pheochromocytoma, and the neuropeptide regulates the differentiation and activity of sympathoadrenal-derived tumoral cell lines, suggestive of an important role in the pathophysiology of the sympathoadrenal lineage. Transcriptome studies uncovered genes and pathways of known and unknown roles that underlie the effects of PACAP in the sympathoadrenal system.

AB - Sympathetic neurons and chromaffin cells derive from common sympathoadrenal precursors which arise from the neural crest. Cells from this lineage migrate to their final destination and differentiate by acquiring a catecholaminergic phenotype in response to different environmental factors. It has been shown that the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its PAC1 receptor are expressed at early stages of sympathetic development, and participate to the control of neuroblast proliferation and differentiation. PACAP also acts as a neurotransmitter to stimulate catecholamine and neuropeptide biosynthesis and release from sympathetic neurons and chromaffin cells, during development and in adulthood. In addition, PACAP and its receptors have been described in neuroblastoma and pheochromocytoma, and the neuropeptide regulates the differentiation and activity of sympathoadrenal-derived tumoral cell lines, suggestive of an important role in the pathophysiology of the sympathoadrenal lineage. Transcriptome studies uncovered genes and pathways of known and unknown roles that underlie the effects of PACAP in the sympathoadrenal system.

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KW - Differentiation

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KW - Neuropeptides

KW - PACAP

KW - Pheochromocytoma

KW - Sympathetic neurons

KW - Transcriptome

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Role of PACAP in the physiology and pathology of the sympathoadrenal system

Abstract

Keywords

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