Role of oxytocin in social cognition in psychosis spectrum disorders

Caridad Benavides, Sharely Fred-Torres, Sarah Barbara Rutter, Emmett Larsen, Jarrett Fastman, Andrea Bulbena-Cabre, Lauren Lepow, Katie Mahon, Manuela Russo, Allison K. Ungar, Katherine Elizabeth Burdick, Maria Mercedes Perez-Rodriguez

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Social cognition deficits are recognized as key features of psychotic disorders, causing significant disability. Recent evidence supports that oxytocin may be a promising treatment to enhance social cognition. In this chapter, we review the biology of endogenous oxytocin, the mechanisms of action of exogenous oxytocin, and the role of oxytocin in social cognition. We present an overview of the current evidence by summarizing clinical trials of oxytocin across the spectrum of psychotic disorders. We also describe the results of clinical trials combining oxytocin with either psychotherapy or cognitive behavioral interventions. The latest literature has demonstrated that oxytocin may improve social cognition in severe mental disorders. Further studies are needed to clarify the therapeutic potential of oxytocin as a treatment for social cognitive deficits in psychotic disorders, and to develop specific evidence-based clinical guidelines.

Original languageEnglish
Title of host publicationSocial Cognition in Psychosis
Number of pages33
ISBN (Electronic)9780128153154
StatePublished - 1 Jan 2019


  • Attributional style
  • Bipolar disorder
  • Emotion recognition
  • Oxytocin
  • Psychosis
  • Schizophrenia
  • Schizotypal personality disorder
  • Social cognition
  • Theory of mind


Dive into the research topics of 'Role of oxytocin in social cognition in psychosis spectrum disorders'. Together they form a unique fingerprint.

Cite this