Role of oxygen radicals in ocular inflammation and cellular damage

Tom Mittag

doi:10.1016/0014-4835(84)90075-7

Role of oxygen radicals in ocular inflammation and cellular damage

Tom Mittag

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Oxyradicals probably play a major role in a number of specific pathological conditions of intraocular tissues, such as cataract formation and retinal degeneration. This paper reviews some of the mechanistic concepts relating to tissue damage by highly reactive oxidants derived from endogenous precursors, hydrogen peroxide and superoxide. Experimental generation of superoxide in the anterior chamber of the rabbit eye showed leucocyte infiltration to be the principal acute response occurring in 4 hr. This finding suggests that superoxide may play a significant role in the ocular inflammatory response, possibly by reacting with a precursor substance in the aqueous humor to produce a chemotactic factor as has been previously found for blood plasma.

Original language	English
Pages (from-to)	759-769
Number of pages	11
Journal	Experimental Eye Research
Volume	39
Issue number	6
DOIs	https://doi.org/10.1016/0014-4835(84)90075-7
State	Published - Dec 1984

Keywords

cataract
hydrogen peroxide
lipid peroxidation
ocular inflammation
retinal degeneration
superoxide radical

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10.1016/0014-4835(84)90075-7

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title = "Role of oxygen radicals in ocular inflammation and cellular damage",

abstract = "Oxyradicals probably play a major role in a number of specific pathological conditions of intraocular tissues, such as cataract formation and retinal degeneration. This paper reviews some of the mechanistic concepts relating to tissue damage by highly reactive oxidants derived from endogenous precursors, hydrogen peroxide and superoxide. Experimental generation of superoxide in the anterior chamber of the rabbit eye showed leucocyte infiltration to be the principal acute response occurring in 4 hr. This finding suggests that superoxide may play a significant role in the ocular inflammatory response, possibly by reacting with a precursor substance in the aqueous humor to produce a chemotactic factor as has been previously found for blood plasma.",

keywords = "cataract, hydrogen peroxide, lipid peroxidation, ocular inflammation, retinal degeneration, superoxide radical",

author = "Tom Mittag",

note = "Funding Information: * Presented in part at the Fifth International Congress of Eye Research, Veldhoven, The Netherlands, October 1982. Supported by USPHS grant EY-02619 and by the Dysautonomia Foundation, Inc. t Correspondence to T. W. Mittag, Ph.D.. Department of Pharmacology, Mount Sinai School Medicine, 1 Gustave L. Levy Place, New York, New York 10029, U.S.il.",

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N2 - Oxyradicals probably play a major role in a number of specific pathological conditions of intraocular tissues, such as cataract formation and retinal degeneration. This paper reviews some of the mechanistic concepts relating to tissue damage by highly reactive oxidants derived from endogenous precursors, hydrogen peroxide and superoxide. Experimental generation of superoxide in the anterior chamber of the rabbit eye showed leucocyte infiltration to be the principal acute response occurring in 4 hr. This finding suggests that superoxide may play a significant role in the ocular inflammatory response, possibly by reacting with a precursor substance in the aqueous humor to produce a chemotactic factor as has been previously found for blood plasma.

AB - Oxyradicals probably play a major role in a number of specific pathological conditions of intraocular tissues, such as cataract formation and retinal degeneration. This paper reviews some of the mechanistic concepts relating to tissue damage by highly reactive oxidants derived from endogenous precursors, hydrogen peroxide and superoxide. Experimental generation of superoxide in the anterior chamber of the rabbit eye showed leucocyte infiltration to be the principal acute response occurring in 4 hr. This finding suggests that superoxide may play a significant role in the ocular inflammatory response, possibly by reacting with a precursor substance in the aqueous humor to produce a chemotactic factor as has been previously found for blood plasma.

KW - cataract

KW - hydrogen peroxide

KW - lipid peroxidation

KW - ocular inflammation

KW - retinal degeneration

KW - superoxide radical

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JO - Experimental Eye Research

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Role of oxygen radicals in ocular inflammation and cellular damage

Abstract

Keywords

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