Role of oxygen radicals in ocular inflammation and cellular damage

Tom Mittag

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Oxyradicals probably play a major role in a number of specific pathological conditions of intraocular tissues, such as cataract formation and retinal degeneration. This paper reviews some of the mechanistic concepts relating to tissue damage by highly reactive oxidants derived from endogenous precursors, hydrogen peroxide and superoxide. Experimental generation of superoxide in the anterior chamber of the rabbit eye showed leucocyte infiltration to be the principal acute response occurring in 4 hr. This finding suggests that superoxide may play a significant role in the ocular inflammatory response, possibly by reacting with a precursor substance in the aqueous humor to produce a chemotactic factor as has been previously found for blood plasma.

Original languageEnglish
Pages (from-to)759-769
Number of pages11
JournalExperimental Eye Research
Volume39
Issue number6
DOIs
StatePublished - Dec 1984

Keywords

  • cataract
  • hydrogen peroxide
  • lipid peroxidation
  • ocular inflammation
  • retinal degeneration
  • superoxide radical

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