Role of magnesium in cardiovascular diseases

Dhaval Kolte, Krishnaswami Vijayaraghavan, Sahil Khera, Domenic A. Sica, William H. Frishman

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations


Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus central to the pathogenesis of several cardiovascular disorders such as hypertension, atherosclerosis, coronary artery disease, congestive heart failure, and cardiac arrhythmias. This review discusses the vasodilatory, anti-inflammatory, anti-ischemic, and antiarrhythmic properties of magnesium and its current role in the prevention and treatment of cardiovascular disorders.

Original languageEnglish
Pages (from-to)182-192
Number of pages11
JournalCardiology in Review
Issue number4
StatePublished - 2014
Externally publishedYes


  • Magnesium
  • arrhythmia
  • cardiovascular diseases
  • hypertension


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