Role of lymphatic vasculature in regional and distant metastases

Simona Podgrabinska, Mihaela Skobe

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


In cancer, lymphatic vasculature has been traditionally viewed only as a transportation system for metastatic cells. It has now become clear that lymphatics perform many additional functions which could influence cancer progression. Lymphangiogenesis, induced at the primary tumor site and at distant sites, potently augments metastasis. Lymphatic endothelial cells (LECs) control tumor cell entry and exit from the lymphatic vessels. LECs also control immune cell traffic and directly modulate adaptive immune responses. This review highlights advances in our understanding of the mechanisms by which lymphatic vessels, and in particular lymphatic endothelium, impact metastasis.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalMicrovascular Research
Issue number1
StatePublished - 2014


  • CCL1
  • CCR8
  • Chemokine
  • Immunoregulation
  • Lymph node
  • Lymphangiogenesis
  • Lymphatic endothelium
  • Metastasis
  • VEGF-C
  • VEGFR-3


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