Role of Insulin Resistance and Hyperglycemia in the Development of Atherosclerosis

Sameer Bansilal, Michael E. Farkouh, Valentin Fuster

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Insulin resistance (IR) is the underlying defect in >90% of patients with type 2 diabetes mellitus and the major pathologic mechanism for the associated susceptibility to premature cardiovascular disease (CVD). The progression of IR to diabetes parallels the progression of endothelial dysfunction to atherosclerosis. The downregulation of the antiatherogenic phosphatidylinositol-3-kinase-mediated insulin receptor-signaling pathway, and maintained activity of the proatherogenic mitogenic-activated protein kinase pathway in insulin-resistant states, leads to accelerated atherosclerosis. Efforts to prevent or slow the epidemic of atherothrombotic CVD must focus on the reversal of the disturbances in glucose and lipid homeostasis through the amelioration of IR.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalAmerican Journal of Cardiology
Volume99
Issue number4 SUPPL.
DOIs
StatePublished - 2007

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