Role of Immunotherapy in Ameliorating Proteopathic Dementia

Dementia is a syndrome that marks a significant cognitive decline with an estimated 50 million populations being affected by this globally and addition of ten million cases every year predicting a compelling threat to society. It commonly involves the neuronal accumulation of proteins leading to protein toxicity, transmission interruptions, cognitive dysfunction, and eventually neuronal death. Currently, novel techniques using different protocols for early theragnostic and prognosis of this age-related disorder have been analyzed to develop efficient and reproducible combinatorial and biologically viable options. Subsequently, immunotherapies have gained much importance among the researchers with promising leads to control and avert the dementing process, while specifically targeting the senile plaques and protein accumulation to control neurotoxicity in neurodegenerative disorders (NDDs). Therefore, in this chapter authors have explored all the reported and possible immunologically applicable options for improving the further cognitive decline in dementia.