Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions

Georgios A. Maragkos; Georgios Mantziaris; Shayan Moosa; W. Jeffrey Elias

doi:10.1002/9781119799627_24

Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions

Georgios A. Maragkos, Georgios Mantziaris, Shayan Moosa, W. Jeffrey Elias

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

MRI-guided focused ultrasound (MRgFUS) is increasingly used in lesioning for functional neurosurgery and neuro-oncology. Technological advances in transducer design and MR thermometry has allowed for the noninvasive lesioning of deep-seated structures under real-time monitoring. MRgFUS has received FDA approval for the treatment of medication-refractory essential tremor and tremor or dyskinesia in Parkinson's disease. These indications might soon expand to include neuropathic pain, obsessive-compulsive disorder, and major depressive disorder, with the culmination of clinical studies currently underway. In the field of neuro-oncology, sonodynamic ablation and histotripsy might help overcome the inherent limitations of the currently available MRgFUS technology in regard to tumor ablation. FUS-mediated blood–brain barrier disruption is also being currently investigated as a mean toward enhancing the availability of chemotherapeutic agents.

Original language	English
Title of host publication	The Application of Heat in Oncology
Subtitle of host publication	Principles and Practice
Publisher	wiley
Pages	403-423
Number of pages	21
ISBN (Electronic)	9781119799627
ISBN (Print)	9781119799597
DOIs	https://doi.org/10.1002/9781119799627_24
State	Published - 1 Jan 2023
Externally published	Yes

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Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions

Abstract

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