Role of ethamsylate in preventing periventricular-intraventricular hemorrhage in premature infants below 34 weeks of gestation

K. P. Sanghvi, R. H. Merchant, Alka Karnik, Aparna Kulkarni

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objective: To determine the role of ethamsylate in prevention of PVH- IVH in premature infants <34 weeks gestational age. Design: Prospective, randomized, controlled study. Methods: Infants less than 34 weeks gestational age were included in the trial. Neonates with congenital malformations, family history of bleeding disorders and with Apgar scores <5 at 5 minutes were excluded. Subjects were randomized into two groups - Group A infants received intravenous ethamsylate (12.5 mg/kg) six hourly for four days and Group B infants served as a control group. Regular cranial ultrasounds to detect the presence of PVH-IVH were done between days 3-5, 10-14 and 28-30 of post natal age, and before hospital discharge in all infants and weekly in infants detected to have PVH-IVH on earlier scans. Various antenatal and postnatal factors known to affect the incidence of PVH-IVH were recorded. Results: A total of 192 infants underwent the trial, 93 in Group A and 99 in Group B. Antenatal corticosteroids (1 or 2 doses) were administered to 32 (34.4%) and 36 (36.3%) women in Group A and Group B, respectively. None of the mothers received phenobarbitone, vitamin K or indomethacin antenatally and none of the infants received phenobarbitone, vitamin E or indomethacin postnatally during the study period. PVH-IVH was seen in 26 infants in Group A, of which Grade I IVH occurred in 9, Grade II in 14, Grade III in 2 and Grade IV in one infant. Twenty-nine infants had PVH-IVH in Group B of which 11 had Grade I, 15 Grade II and 3 Grade III. None of the differences were statistically significant. Conclusion: Postnatal administration of ethamsylate did not decrease the incidence of PVH-IVH in the study infants.

Original languageEnglish
Pages (from-to)653-658
Number of pages6
JournalIndian Pediatrics
Volume36
Issue number7
StatePublished - Jul 1999
Externally publishedYes

Keywords

  • Ethamsylate
  • Periventricular-intraventricular hemorrhage
  • Premature infants

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